| Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme RG Silva, AS Murkin, VL Schramm Proceedings of the National Academy of Sciences 108 (46), 18661-18665, 2011 | 130 | 2011 |
| Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases GB Evans, RH Furneaux, B Greatrex, AS Murkin, VL Schramm, PC Tyler Journal of medicinal chemistry 51 (4), 948-956, 2008 | 100 | 2008 |
| Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening E Bettiol, M Samanovic, AS Murkin, J Raper, F Buckner, A Rodriguez PLoS neglected tropical diseases 3 (2), e384, 2009 | 96 | 2009 |
| Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase K Clinch, GB Evans, RFG Fröhlich, RH Furneaux, PM Kelly, L Legentil, ... Journal of medicinal chemistry 52 (4), 1126-1143, 2009 | 84 | 2009 |
| New electrophiles and strategies for mechanism-based and targeted covalent inhibitor design S Ray, AS Murkin Biochemistry 58 (52), 5234-5244, 2019 | 82 | 2019 |
| Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model MB Cassera, KZ Hazleton, EF Merino, N Obaldia III, MC Ho, AS Murkin, ... PLoS One 6 (11), e26916, 2011 | 77 | 2011 |
| The NeuC Protein of Escherichia coli K1 Is a UDP N-Acetylglucosamine 2-Epimerase WF Vann, DA Daines, AS Murkin, ME Tanner, DO Chaffin, CE Rubens, ... Journal of bacteriology 186 (3), 706-712, 2004 | 76 | 2004 |
| Neighboring group participation in the transition state of human purine nucleoside phosphorylase AS Murkin, MR Birck, A Rinaldo-Matthis, W Shi, EA Taylor, VL Schramm Biochemistry 46 (17), 5038-5049, 2007 | 64 | 2007 |
| Highly Precise Measurement of Kinetic Isotope Effects Using 1H-Detected 2D [13C,1H]-HSQC NMR Spectroscopy KA Manning, B Sathyamoorthy, A Eletsky, T Szyperski, AS Murkin Journal of the American Chemical Society 134 (51), 20589-20592, 2012 | 53 | 2012 |
| A β-fluoroamine inhibitor of purine nucleoside phosphorylase JM Mason, AS Murkin, L Li, VL Schramm, GJ Gainsford, BW Skelton Journal of medicinal chemistry 51 (18), 5880-5884, 2008 | 50 | 2008 |
| Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis TV Pham, AS Murkin, MM Moynihan, L Harris, PC Tyler, N Shetty, ... Proceedings of the National Academy of Sciences 114 (29), 7617-7622, 2017 | 47 | 2017 |
| Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase AS Murkin, KA Manning, SA Kholodar Bioorganic Chemistry 57, 171-185, 2014 | 45 | 2014 |
| Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase AS Murkin, WK Chou, WW Wakarchuk, ME Tanner Biochemistry 43 (44), 14290-14298, 2004 | 45 | 2004 |
| Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate MM Moynihan, AS Murkin Biochemistry 53 (1), 178-187, 2014 | 41 | 2014 |
| Transition state analogue discrimination by related purine nucleoside phosphorylases EA Taylor Ringia, PC Tyler, GB Evans, RH Furneaux, AS Murkin, ... Journal of the American Chemical Society 128 (22), 7126-7127, 2006 | 40 | 2006 |
| The nitro group as a masked electrophile in covalent enzyme inhibition S Ray, DF Kreitler, AM Gulick, AS Murkin ACS chemical biology 13 (6), 1470-1473, 2018 | 37 | 2018 |
| Dehydroalanine-based inhibition of a peptide epimerase from spider venom AS Murkin, ME Tanner The Journal of Organic Chemistry 67 (24), 8389-8394, 2002 | 34 | 2002 |
| Inverse solvent isotope effects in enzyme-catalyzed reactions PL Fernandez, AS Murkin Molecules 25 (8), 1933, 2020 | 31 | 2020 |
| DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group SA Kholodar, AS Murkin Biochemistry 52 (13), 2302-2308, 2013 | 24 | 2013 |
| Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects AS Murkin, PC Tyler, VL Schramm Journal of the American Chemical Society 130 (7), 2166-2167, 2008 | 24 | 2008 |
Peter C TylerFerrier Research Institute, Victoria University of WellingtonVerified email at vuw.ac.nz
