| Prediction and reduction of the aggregation of monoclonal antibodies R van der Kant, AR Karow-Zwick, J Van Durme, M Blech, R Gallardo, ... Journal of molecular biology 429 (8), 1244-1261, 2017 | 145 | 2017 |
| GPCRDB: an information system for G protein-coupled receptors V Isberg, B Vroling, R van der Kant, K Li, G Vriend, D Gloriam Nucleic acids research 42 (D1), D422-D425, 2014 | 138 | 2014 |
| Hsp90 mediates membrane deformation and exosome release E Lauwers, YC Wang, R Gallardo, R Van der Kant, E Michiels, J Swerts, ... Molecular cell 71 (5), 689-702. e9, 2018 | 137 | 2018 |
| Solubis: a webserver to reduce protein aggregation through mutation J Van Durme, G De Baets, R Van Der Kant, M Ramakers, A Ganesan, ... Protein Engineering, Design and Selection 29 (8), 285-289, 2016 | 67 | 2016 |
| Post-translational control of the temporal dynamics of transcription factor activity regulates neurogenesis XJ Quan, L Yuan, L Tiberi, A Claeys, N De Geest, J Yan, R Van Der Kant, ... Cell 164 (3), 460-475, 2016 | 64 | 2016 |
| Structural hot spots for the solubility of globular proteins A Ganesan, A Siekierska, J Beerten, M Brams, J Van Durme, G De Baets, ... Nature communications 7 (1), 10816, 2016 | 62 | 2016 |
| Alpha-bulges in G protein-coupled receptors R Van der Kant, G Vriend International journal of molecular sciences 15 (5), 7841-7864, 2014 | 45 | 2014 |
| Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia E Van Nieuwenhove, JS Barber, J Neumann, E Smeets, M Willemsen, ... Journal of Allergy and Clinical Immunology 146 (5), 1180-1193, 2020 | 39 | 2020 |
| Thermodynamic and evolutionary coupling between the native and amyloid state of globular proteins T Langenberg, R Gallardo, R van der Kant, N Louros, E Michiels, ... Cell reports 31 (2), 2020 | 37 | 2020 |
| Reverse engineering synthetic antiviral amyloids E Michiels, K Roose, R Gallardo, L Khodaparast, L Khodaparast, ... Nature communications 11 (1), 2832, 2020 | 35 | 2020 |
| Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues B Houben, E Michiels, M Ramakers, K Konstantoulea, N Louros, ... The EMBO journal 39 (11), e102864, 2020 | 32 | 2020 |
| Thermodynamic analysis of amyloid fibril structures reveals a common framework for stability in amyloid polymorphs R van der Kant, N Louros, J Schymkowitz, F Rousseau Structure 30 (8), 1178-1189. e3, 2022 | 23* | 2022 |
| Solubis: optimize your protein G De Baets, J Van Durme, R van der Kant, J Schymkowitz, F Rousseau Bioinformatics 31 (15), 2580-2582, 2015 | 22 | 2015 |
| Adaption of human antibody λ and κ light chain architectures to CDR repertoires R van der Kant, J Bauer, AR Karow-Zwick, S Kube, P Garidel, M Blech, ... Protein Engineering, Design and Selection 32 (3), 109-127, 2019 | 15 | 2019 |
| The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis N Guthertz, R Van Der Kant, RM Martinez, Y Xu, CH Trinh, BI Iorga, ... Proceedings of the National Academy of Sciences 119 (22), e2200468119, 2022 | 10 | 2022 |
| StAmP-DB: a platform for structures of polymorphic amyloid fibril cores N Louros, R Van Der Kant, J Schymkowitz, F Rousseau Bioinformatics 38 (9), 2636-2638, 2022 | 10 | 2022 |
| SolubiS: Optimizing protein solubility by minimal point mutations R van der Kant, J van Durme, F Rousseau, J Schymkowitz Protein Misfolding Diseases: Methods and Protocols, 317-333, 2019 | 9 | 2019 |
| Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V F Claes, S Rudyak, AS Laird, N Louros, J Beerten, M Debulpaep, ... Protein Engineering, Design and Selection 32 (10), 443-457, 2019 | 6 | 2019 |
| Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein K Janssen, F Claes, D Van de Velde, VL Wehbi, B Houben, Y Lampi, ... Proceedings of the National Academy of Sciences 120 (9), e2214921120, 2023 | 3 | 2023 |
| De novo design of high-affinity single-domain antibodies R Van Der Kant, Z Zhang, I Marković, D Vizarraga, T Garcia, K Maragkou, ... bioRxiv, 2024.04. 22.589762, 2024 | | 2024 |
Nikolaos LourosAssistant Professor, UT Soutwestern Medical CenterVerified email at utsouthwestern.edu
