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Mikkel Wandahl Pedersen
Mikkel Wandahl Pedersen
EVP and CSO Nykode Therapeutics
Подтвержден адрес электронной почты в домене nykode.com - Главная страница
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Targeting the ERBB family in cancer: couples therapy
N Tebbutt, MW Pedersen, TG Johns
Nature Reviews Cancer 13 (9), 663-673, 2013
4962013
The type III epidermal growth factor receptor mutation: biological significance and potential target for anti-cancer therapy
MW Pedersen, M Meltorn, L Damstrup, HS Poulsen
Annals of oncology 12 (6), 745-760, 2001
3442001
Sym004: a novel synergistic anti–epidermal growth factor receptor antibody mixture with superior anticancer efficacy
MW Pedersen, HJ Jacobsen, K Koefoed, A Hey, C Pyke, JS Haurum, ...
Cancer research 70 (2), 588-597, 2010
2692010
The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers
GG Duthie, MW Pedersen, PT Gardner, PC Morrice, AME Jenkinson, ...
European Journal of Clinical Nutrition 52 (10), 733-736, 1998
2441998
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes
MV Grandal, R Zandi, MW Pedersen, BM Willumsen, B van Deurs, ...
Carcinogenesis 28 (7), 1408-1417, 2007
1972007
Activation of the EGFR gene target EphA2 inhibits epidermal growth factor–induced cancer cell motility
AB Larsen, MW Pedersen, MT Stockhausen, MV Grandal, B Deurs, ...
Molecular cancer research 5 (3), 283-293, 2007
1672007
Transcriptional gene expression profiling of small cell lung cancer cells
N Pedersen, S Mortensen, SB Sørensen, MW Pedersen, K Rieneck, ...
Cancer research 63 (8), 1943-1953, 2003
1352003
Efficacy of Sym004 in patients with metastatic colorectal cancer with acquired resistance to anti-EGFR therapy and molecularly selected by circulating tumor DNA analyses: a …
C Montagut, G Argilés, F Ciardiello, TT Poulsen, R Dienstmann, M Kragh, ...
JAMA oncology 4 (4), e175245-e175245, 2018
1102018
Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor
K Koefoed, L Steinaa, JN Søderberg, I Kjær, HJ Jacobsen, PJ Meijer, ...
MAbs 3 (6), 584-595, 2011
1092011
Expression of a naturally occurring constitutively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility
MW Pedersen, V Tkach, N Pedersen, V Berezin, HS Poulsen
International journal of cancer 108 (5), 643-653, 2004
1032004
Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro
J Vestergaard, MW Pedersen, N Pedersen, C Ensinger, Z Tümer, ...
Lung cancer 52 (3), 281-290, 2006
982006
Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII
MW Pedersen, N Pedersen, LH Ottesen, HS Poulsen
British journal of cancer 93 (8), 915-923, 2005
882005
Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, effectively overcomes tumor heterogeneity and plasticity
HJ Jacobsen, TT Poulsen, A Dahlman, I Kjær, K Koefoed, JW Sen, ...
Clinical Cancer Research 21 (18), 4110-4122, 2015
852015
Safety and activity of the first-in-class Sym004 anti-EGFR antibody mixture in patients with refractory colorectal cancer
R Dienstmann, A Patnaik, R Garcia-Carbonero, A Cervantes, M Benavent, ...
Cancer Discovery 5 (6), 598-609, 2015
822015
Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab
M Iida, TM Brand, MM Starr, C Li, EJ Huppert, N Luthar, MW Pedersen, ...
Neoplasia 15 (10), 1196-1206, 2013
742013
Analysis of the epidermal growth factor receptor specific transcriptome: effect of receptor expression level and an activating mutation
MW Pedersen, N Pedersen, L Damstrup, M Villingshøj, SU Sønder, ...
Journal of cellular biochemistry 96 (2), 412-427, 2005
712005
The insulinoma-associated 1: a novel promoter for targeted cancer gene therapy for small-cell lung cancer
N Pedersen, MW Pedersen, MS Lan, MB Breslin, HS Poulsen
Cancer gene therapy 13 (4), 375-384, 2006
652006
Oncology drug innovation
H Poulsen, N Pedersen, S Mortensen, S Sorensen, M Pedersen, H Elsner
US Patent App. 10/482,029, 2005
632005
EGFR induces expression of IRF‐1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells
P Andersen, MW Pedersen, A Woetmann, M Villingshøj, MT Stockhausen, ...
International journal of cancer 122 (2), 342-349, 2008
622008
Targeting three distinct HER2 domains with a recombinant antibody mixture overcomes trastuzumab resistance
MW Pedersen, HJ Jacobsen, K Koefoed, A Dahlman, I Kjær, TT Poulsen, ...
Molecular Cancer Therapeutics 14 (3), 669-680, 2015
602015
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