A deep learning approach to antibiotic discovery JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, ... Cell 180 (4), 688-702. e13, 2020 | 2043 | 2020 |
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ... Nature microbiology 2 (5), 1-8, 2017 | 329 | 2017 |
Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics CR MacNair, JM Stokes, LA Carfrae, AA Fiebig-Comyn, BK Coombes, ... Nature communications 9 (1), 458, 2018 | 292 | 2018 |
Uncovering the Hidden Antibiotic Potential of Cannabis ED Farha, M. A., El-Halfawy, O. M., Gale, R. T., MacNair, C. R., Carfrae, L ... ACS infectious diseases 6 (3), 338-346, 2020 | 144 | 2020 |
Outer membrane disruption overcomes intrinsic, acquired, and spontaneous antibiotic resistance CR MacNair, ED Brown MBio 11 (5), 10.1128/mbio. 01615-20, 2020 | 80 | 2020 |
The genome-wide interaction network of nutrient stress genes in Escherichia coli JP Côté, S French, SS Gehrke, CR MacNair, CS Mangat, A Bharat, ... MBio 7 (6), 10.1128/mbio. 01714-16, 2016 | 60* | 2016 |
Alternative therapeutic strategies to treat antibiotic-resistant pathogens CR MacNair, ST Rutherford, MW Tan Nature Reviews Microbiology 22 (5), 262-275, 2024 | 53 | 2024 |
Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens LA Carfrae, CR MacNair, CM Brown, CN Tsai, BS Weber, S Zlitni, VN Rao, ... Nature Microbiology 5 (1), 93-101, 2020 | 43 | 2020 |
Creative targeting of the Gram‐negative outer membrane in antibiotic discovery CR MacNair, CN Tsai, ED Brown Annals of the New York Academy of Sciences 1459 (1), 69-85, 2020 | 39 | 2020 |
Targeting two-component systems uncovers a small-molecule inhibitor of Salmonella virulence CN Tsai, CR MacNair, MPT Cao, JN Perry, J Magolan, ED Brown, ... Cell chemical biology 27 (7), 793-805. e7, 2020 | 35 | 2020 |
Inhibiting fatty acid synthesis overcomes colistin resistance LA Carfrae, K Rachwalski, S French, R Gordzevich, L Seidel, CN Tsai, ... Nature Microbiology 8 (6), 1026-1038, 2023 | 31 | 2023 |
A genetic platform to investigate the functions of bacterial drug efflux pumps T Teelucksingh, LK Thompson, S Zhu, NM Kuehfuss, JA Goetz, SE Gilbert, ... Nature Chemical Biology 18 (12), 1399-1409, 2022 | 25 | 2022 |
Overcoming acquired and native macrolide resistance with bicarbonate MA Farha, CR MacNair, LA Carfrae, SS El Zahed, MJ Ellis, HKR Tran, ... ACS Infectious Diseases 6 (10), 2709-2718, 2020 | 24 | 2020 |
Preclinical development of pentamidine analogs identifies a potent and nontoxic antibiotic adjuvant CR MacNair, MA Farha, MH Serrano-Wu, KK Lee, B Hubbard, JP Côté, ... ACS Infectious Diseases 8 (4), 768-777, 2022 | 21 | 2022 |
Antibacterial activity of metergoline analogues: revisiting the ergot alkaloid scaffold for antibiotic discovery JW Johnson, MJ Ellis, ZA Piquette, C MacNair, L Carfrae, T Bhando, ... ACS Medicinal Chemistry Letters 13 (2), 284-291, 2022 | 19 | 2022 |
Management of phytophthora blight (Phytophthora capsici) on vegetables in Ontario: some greenhouse and field aspects RF Cerkauskas, G Ferguson, C MacNair Canadian Journal of Plant Pathology 37 (3), 285-304, 2015 | 17 | 2015 |
The role of bacterial membrane vesicles in antibiotic resistance CR MacNair, MW Tan Annals of the New York Academy of Sciences 1519 (1), 63-73, 2023 | 14 | 2023 |
Exploiting the sensitivity of nutrient transporter deletion strains in discovery of natural product antimetabolites SS Gehrke, G Kumar, NA Yokubynas, JP Côté, W Wang, S French, ... ACS Infectious Diseases 3 (12), 955-965, 2017 | 13 | 2017 |
Bicarbonate as a potentiator for antimicrobial agents E Brown, M Farha, C MacNair, J Stokes US Patent 10,940,163, 2021 | 12 | 2021 |
Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium MJ Ellis, LA Carfrae, CR Macnair, RS Trussler, ED Brown, DB Haniford RNA biology 15 (2), 176-181, 2018 | 9 | 2018 |