| Intranasal delivery of biologics to the central nervous system JJ Lochhead, RG Thorne Advanced drug delivery reviews 64 (7), 614-628, 2012 | 1131 | 2012 |
| Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results DL Sparks, MN Sabbagh, DJ Connor, J Lopez, LJ Launer, P Browne, ... Archives of neurology 62 (5), 753-757, 2005 | 570 | 2005 |
| Oxidative stress increases blood–brain barrier permeability and induces alterations in occludin during hypoxia–reoxygenation JJ Lochhead, G McCaffrey, CE Quigley, J Finch, KM DeMarco, N Nametz, ... Journal of Cerebral Blood Flow & Metabolism 30 (9), 1625-1636, 2010 | 352 | 2010 |
| Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne Journal of Cerebral Blood Flow & Metabolism 35 (3), 371-381, 2015 | 255 | 2015 |
| Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders JJ Lochhead, J Yang, PT Ronaldson, TP Davis Frontiers in physiology 11, 558491, 2020 | 238 | 2020 |
| Occludin oligomeric assemblies at tight junctions of the blood–brain barrier are altered by hypoxia and reoxygenation stress G McCaffrey, CL Willis, WD Staatz, N Nametz, CA Quigley, S Hom, ... Journal of neurochemistry 110 (1), 58-71, 2009 | 104 | 2009 |
| Distribution of insulin in trigeminal nerve and brain after intranasal administration JJ Lochhead, KL Kellohen, PT Ronaldson, TP Davis Scientific reports 9 (1), 2621, 2019 | 101 | 2019 |
| Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD DL Sparks, MN Sabbagh, DJ Connor, J Lopez, LJ Launer, S Petanceska, ... Current Alzheimer Research 2 (3), 343-353, 2005 | 95 | 2005 |
| Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery NN Kumar, JJ Lochhead, ME Pizzo, G Nehra, S Boroumand, G Greene, ... Journal of controlled release 286, 467-484, 2018 | 86 | 2018 |
| Hypoxic stress and inflammatory pain disrupt blood-brain barrier tight junctions: implications for drug delivery to the central nervous system JJ Lochhead, PT Ronaldson, TP Davis The AAPS Journal 19, 910-920, 2017 | 75 | 2017 |
| Perivascular and perineural pathways involved in brain delivery and distribution of drugs after intranasal administration JJ Lochhead, TP Davis Pharmaceutics 11 (11), 598, 2019 | 63 | 2019 |
| Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain JJ Lochhead, G McCaffrey, L Sanchez-Covarrubias, JD Finch, ... American Journal of Physiology-Heart and Circulatory Physiology 302 (3 …, 2012 | 51 | 2012 |
| Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid β (Aβ) in rabbit brain DL Sparks, J Lochhead, D Horstman, T Wagoner, T Martin Journal of Alzheimer's Disease 4 (6), 523-529, 2002 | 49 | 2002 |
| Cholesterol, copper and Aβ in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT) DL Sparks, S Petanceska, M Sabbagh, D Connor, H Soares, C Adler, ... Current Alzheimer Research 2 (5), 527-539, 2005 | 48 | 2005 |
| Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery NN Kumar, M Gautam, JJ Lochhead, DJ Wolak, V Ithapu, V Singh, ... Scientific reports 6 (1), 31732, 2016 | 46 | 2016 |
| Intranasal drug delivery to the brain JJ Lochhead, RG Thorne Drug delivery to the brain: physiological concepts, methodologies and …, 2013 | 36 | 2013 |
| Cholesterol modifies classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response. BG Schreurs, CA Smith-Bell, J Lochhead, DL Sparks Behavioral Neuroscience 117 (6), 1220, 2003 | 27 | 2003 |
| Benefit of atorvastatin in the treatment of Alzheimer disease DL Sparks, D Connor, J Lopez, L Launer, S Petanceska, L Baxter, ... Neurobiol Aging 25 (Suppl 1), S24, 2004 | 13 | 2004 |
| βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling EA Kwak, CC Pan, A Ramonett, S Kumar, P Cruz-Flores, T Ahmed, ... Nature communications 13 (1), 1326, 2022 | 12 | 2022 |
| Regulation of blood-brain barrier transporters by transforming growth factor-β/Activin Receptor-Like Kinase 1 Signaling: relevance to the brain disposition of 3-hydroxy-3 … RD Betterton, W Abdullahi, EI Williams, JJ Lochhead, H Brzica, J Stanton, ... Drug Metabolism and Disposition 50 (7), 942-956, 2022 | 10 | 2022 |
