| Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ... Science advances 6 (42), eabd4596, 2020 | 329 | 2020 |
| SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging W Rut, K Groborz, L Zhang, X Sun, M Zmudzinski, B Pawlik, X Wang, ... Nature chemical biology 17 (2), 222-228, 2021 | 233 | 2021 |
| Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ... biorxiv, 2020.04. 29.068890, 2020 | 113 | 2020 |
| Small molecule active site directed tools for studying human caspases M Poreba, A Szalek, P Kasperkiewicz, W Rut, GS Salvesen, M Drag Chemical reviews 115 (22), 12546-12629, 2015 | 84 | 2015 |
| Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome I Pablos, Y Machado, HCR de Jesus, Y Mohamud, R Kappelhoff, ... Cell reports 37 (4), 2021 | 70 | 2021 |
| Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes M Poreba, W Rut, M Vizovisek, K Groborz, P Kasperkiewicz, D Finlay, ... Chemical Science 9 (8), 2113-2129, 2018 | 69 | 2018 |
| Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families M Poreba, A Szalek, W Rut, P Kasperkiewicz, I Rutkowska-Wlodarczyk, ... Scientific reports 7 (1), 1-13, 2017 | 67 | 2017 |
| SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme M Békés, W Rut, P Kasperkiewicz, MPC Mulder, H Ovaa, M Drag, ... Biochemical Journal 468 (2), 215-226, 2015 | 66 | 2015 |
| Counter selection substrate library strategy for developing specific protease substrates and probes M Poreba, R Solberg, W Rut, NN Lunde, P Kasperkiewicz, SJ Snipas, ... Cell chemical biology 23 (8), 1023-1035, 2016 | 60 | 2016 |
| Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease W Rut, L Zhang, P Kasperkiewicz, M Poreba, R Hilgenfeld, M Drąg Antiviral research 139, 88-94, 2017 | 59 | 2017 |
| Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design W Rut, K Groborz, L Zhang, X Sun, M Zmudzinski, R Hilgenfeld, M Drag BioRxiv, 2020 | 47 | 2020 |
| A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease S Patchett, Z Lv, W Rut, M Békés, M Drag, SK Olsen, TT Huang Cell Reports 36 (13), 2021 | 35 | 2021 |
| Multiplexed probing of proteolytic enzymes using mass cytometry-compatible activity-based probes M Poreba, KM Groborz, W Rut, M Pore, SJ Snipas, M Vizovisek, B Turk, ... Journal of the American Chemical Society 142 (39), 16704-16715, 2020 | 33 | 2020 |
| Selective substrates and activity-based probes for imaging of the human constitutive 20S proteasome in cells and blood samples W Rut, M Poreba, P Kasperkiewicz, SJ Snipas, M Drag Journal of Medicinal Chemistry 61 (12), 5222-5234, 2018 | 28 | 2018 |
| Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions NN Lunde, MH Haugen, KBB Larsen, I Damgaard, SJ Pettersen, R Kasem, ... Biochimie 139, 27-37, 2017 | 27 | 2017 |
| Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes W Rut, M Zmudzinski, SJ Snipas, M Bekes, TT Huang, M Drag Chemical Science 11 (23), 6058-6069, 2020 | 26 | 2020 |
| Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies M Zmudzinski, W Rut, K Olech, J Granda, M Giurg, M Burda-Grabowska, ... BioRxiv, 2020.08. 30.273979, 2020 | 25 | 2020 |
| Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging W Rut, K Groborz, L Zhang, X Sun, M Zmudzinski, B Pawlik, W Młynarski, ... Biorxiv, 2020.03. 07.981928, 2020 | 24 | 2020 |
| Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells M Poreba, W Rut, K Groborz, SJ Snipas, GS Salvesen, M Drag Cell Death & Differentiation 26 (12), 2695-2709, 2019 | 24 | 2019 |
| Unique substrate specificity of SplE serine protease from Staphylococcus aureus N Stach, M Kalinska, M Zdzalik, R Kitel, A Karim, K Serwin, W Rut, ... Structure 26 (4), 572-579. e4, 2018 | 24 | 2018 |
