Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation MH Høie, M Cagiada, AHB Frederiksen, A Stein, K Lindorff-Larsen Cell reports 38 (2), 2022 | 86 | 2022 |
Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance M Cagiada, KE Johansson, A Valančiūtė, SV Nielsen, ... Molecular Biology and Evolution 95, 2021 | 70 | 2021 |
Rapid protein stability prediction using deep learning representations LM Blaabjerg, MM Kassem, LL Good, N Jonsson, M Cagiada, ... Elife 12, e82593, 2023 | 66 | 2023 |
Discovering functionally important sites in proteins M Cagiada, S Bottaro, S Lindemose, SM Schenstrøm, A Stein, ... Nature communications 14 (1), 4175, 2023 | 32 | 2023 |
A comprehensive map of human glucokinase variant activity S Gersing, M Cagiada, M Gebbia, AP Gjesing, AG Coté, G Seesankar, ... Genome Biology 24 (1), 97, 2023 | 31 | 2023 |
A mutational atlas for Parkin proteostasis L Clausen, V Voutsinos, M Cagiada, KE Johansson, ... Nature Communications 15 (1), 1541, 2024 | 12 | 2024 |
Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components C Kampmeyer, M Grønbæk-Thygesen, N Oelerich, MH Tatham, ... Cellular and Molecular Life Sciences 80 (6), 143, 2023 | 8 | 2023 |
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay S Gersing, TK Schulze, M Cagiada, A Stein, FP Roth, K Lindorff-Larsen, ... Genome Biology 25 (1), 1-22, 2024 | 6 | 2024 |
14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes AP Gjesing, L Engelbrechtsen, ACB Thuesen, CT Have, M Hollensted, ... Diabetes Research and Clinical Practice 194, 110159, 2022 | 6 | 2022 |
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation JL Pacheco-Garcia, M Cagiada, K Tienne-Matos, E Salido, ... Frontiers in Molecular Biosciences 9, 1063620, 2022 | 6 | 2022 |
Statistical mechanical properties of sequence space determine the efficiency of the various algorithms to predict interaction energies and native contacts from protein coevolution G Franco, M Cagiada, G Bussi, G Tiana Physical Biology 16 (4), 046007, 2019 | 5 | 2019 |
Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants M Grønbæk-Thygesen, V Voutsinos, KE Johansson, TK Schulze, ... Nature Communications 15 (1), 4026, 2024 | 3 | 2024 |
Predicting absolute protein folding stability using generative models M Cagiada, S Ovchinnikov, K Lindorff-Larsen bioRxiv, 2024.03. 14.584940, 2024 | 3 | 2024 |
Rare Catechol-O-methyltransferase Missense Variants Are Structurally Unstable Proteasome Targets FB Larsen, M Cagiada, J Dideriksen, A Stein, K Lindorff-Larsen, ... Biochemistry 62 (8), 1394-1405, 2023 | 3 | 2023 |
Deep mutational scanning reveals a tight correlation between protein degradation and toxicity of thousands of non-native aspartoacylase protein variants M Grønbæk-Thygesen, V Voutsinos, KE Johansson, TK Schulze, ... BioRxiv, 2023.10. 02.560410, 2023 | 1 | 2023 |
A multiplexed assay of human glucokinase reveals thousands of potential disease variants with both decreased and increased activity S Gersing, M Cagiada, M Gebbia, AP Gjesing, G Seesankar, A Stein, ... BioRXiv, 2022.05. 04.490571, 2022 | 1 | 2022 |
OPEN ACCESS EDITED BY D Dell'Orco, R Chiaraluce, C Travaglini-Allocatelli, AL Pey, ... Computational and Experimental Protein Variant Interpretation in the Era of …, 2024 | | 2024 |
Decoding molecular mechanisms for loss of function variants in the human proteome M Cagiada, N Jonsson, K Lindorff-Larsen bioRxiv, 2024.05. 21.595203, 2024 | | 2024 |
Prediction of native contacts in proteins from an out--of--equilibrium coevolutionary process D Oriani, M Cagiada, G Tiana arXiv preprint arXiv:2002.03383, 2020 | | 2020 |