| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839, 2012 | 770 | 2012 |
| Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain C Xu, X Wang, K Liu, IA Roundtree, W Tempel, Y Li, Z Lu, C He, J Min Nature chemical biology 10 (11), 927, 2014 | 639 | 2014 |
| A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ... Nature chemical biology 7 (8), 566, 2011 | 547 | 2011 |
| Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation SB Rothbart, K Krajewski, N Nady, W Tempel, S Xue, AI Badeaux, ... Nature structural & molecular biology 19 (11), 1155, 2012 | 404 | 2012 |
| Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development Y Xu, C Xu, A Kato, W Tempel, JG Abreu, C Bian, Y Hu, D Hu, B Zhao, ... Cell 151 (6), 1200-1213, 2012 | 311 | 2012 |
| Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases TL Davis, JR Walker, V Campagna-Slater, PJ Finerty Jr, R Paramanathan, ... PLoS biology 8 (7), e1000439, 2010 | 311 | 2010 |
| Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms M Vedadi, J Lew, J Artz, M Amani, Y Zhao, A Dong, GA Wasney, M Gao, ... Molecular and biochemical parasitology 151 (1), 100-110, 2007 | 303 | 2007 |
| Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ... Nature communications 3, 1288, 2012 | 296 | 2012 |
| In situ proteolysis for protein crystallization and structure determination A Dong, X Xu, AM Edwards, C Chang, M Chruszcz, M Cuff, ... Nature methods 4 (12), 1019, 2007 | 290 | 2007 |
| Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation C Bian, C Xu, J Ruan, KK Lee, TL Burke, W Tempel, D Barsyte, J Li, M Wu, ... The EMBO journal 30 (14), 2829-2842, 2011 | 286 | 2011 |
| Structural and chemical profiling of the human cytosolic sulfotransferases A Allali-Hassani, PW Pan, L Dombrovski, R Najmanovich, W Tempel, ... PLoS biology 5 (5), e97, 2007 | 270 | 2007 |
| Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium AK Wernimont, JD Artz, P Finerty Jr, YH Lin, M Amani, A Allali-Hassani, ... Nature structural & molecular biology 17 (5), 596, 2010 | 233 | 2010 |
| Structural and histone binding ability characterizations of human PWWP domains H Wu, H Zeng, R Lam, W Tempel, MF Amaya, C Xu, L Dombrovski, W Qiu, ... PloS one 6 (6), e18919, 2011 | 192 | 2011 |
| Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain LI James, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, ... Nature chemical biology 9 (3), 184, 2013 | 188 | 2013 |
| Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation C Xu, K Liu, W Tempel, M Demetriades, WS Aik, CJ Schofield, J Min Journal of Biological Chemistry 289 (25), 17299-17311, 2014 | 183 | 2014 |
| Nicotinamide riboside kinase structures reveal new pathways to NAD+ W Tempel, WM Rabeh, KL Bogan, P Belenky, M Wojcik, HF Seidle, ... PLoS biology 5 (10), e263, 2007 | 175 | 2007 |
| A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1 JI Stuckey, BM Dickson, N Cheng, Y Liu, JL Norris, SH Cholensky, ... Nature chemical biology 12 (3), 180, 2016 | 157 | 2016 |
| Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain Y Tong, P Chugha, PK Hota, RS Alviani, M Li, W Tempel, L Shen, ... Journal of Biological Chemistry 282 (51), 37215-37224, 2007 | 155 | 2007 |
| Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases H Wu, L Dombrovsky, W Tempel, F Martin, P Loppnau, GH Goodfellow, ... Journal of Biological Chemistry 282 (41), 30189-30197, 2007 | 152 | 2007 |
| Mechanism of class 1 (glycosylhydrolase family 47) α-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control K Karaveg, A Siriwardena, W Tempel, ZJ Liu, J Glushka, BC Wang, ... Journal of Biological Chemistry 280 (16), 16197-16207, 2005 | 148 | 2005 |
