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Constanza Alcaino
Constanza Alcaino
Verified email at medschl.cam.ac.uk
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Cited by
Year
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
C Alcaino, KR Knutson, AJ Treichel, G Yildiz, PR Strege, DR Linden, JH Li, ...
Proceedings of the National Academy of Sciences 115 (32), E7632-E7641, 2018
2072018
Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces
F Wang, K Knutson, C Alcaino, DR Linden, SJ Gibbons, P Kashyap, ...
The Journal of physiology 595 (1), 79-91, 2017
1522017
Mechanosensitive piezo channels in the gastrointestinal tract
C Alcaino, G Farrugia, A Beyder
Current topics in membranes 79, 219-244, 2017
792017
Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4
C Alcaino, K Knutson, PA Gottlieb, G Farrugia, A Beyder
Channels 11 (3), 245-253, 2017
632017
Non-equivalent ligand selectivity of agonist sites in (α4β2) 2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy
S Mazzaferro, F Gasparri, K New, C Alcaino, M Faundez, PI Vasquez, ...
Journal of Biological Chemistry 289 (31), 21795-21806, 2014
452014
Specialized mechanosensory epithelial cells in mouse gut intrinsic tactile sensitivity
AJ Treichel, I Finholm, KR Knutson, C Alcaino, ST Whiteman, MR Brown, ...
Gastroenterology 162 (2), 535-547. e13, 2022
442022
The additional ACh binding site at the α4(+)/α4(−) interface of the (α4β2)2α4 nicotinic ACh receptor contributes to desensitization
N Benallegue, S Mazzaferro, C Alcaino, I Bermudez
British journal of pharmacology 170 (2), 304-316, 2013
352013
Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors
C Alcaino, M Musgaard, T Minguez, S Mazzaferro, M Faundez, ...
Journal of Biological Chemistry 292 (2), 551-562, 2017
312017
microRNA overexpression in slow transit constipation leads to reduced NaV1. 5 current and altered smooth muscle contractility
A Mazzone, PR Strege, SJ Gibbons, C Alcaino, V Joshi, AJ Haak, ...
Gut 69 (5), 868-876, 2020
202020
NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor
S Mazzaferro, ST Whiteman, C Alcaino, A Beyder, SM Sine
Cellular and Molecular Life Sciences 78, 1565-1575, 2021
142021
Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery
E Mantione, S Micheloni, C Alcaino, K New, S Mazzaferro, I Bermudez
Future Medicinal Chemistry 4 (17), 2217-2230, 2012
142012
Foundation one genomic interrogation of thyroid cancers in patients with metastatic disease requiring systemic therapy
NM Iñiguez-Ariza, S Jasim, MM Ryder, AV Chintakuntlawar, JC Morris III, ...
The Journal of Clinical Endocrinology & Metabolism 105 (7), e2346-e2357, 2020
112020
Identification of intrinsic primary afferent neurons in mouse jejunum
CGS Melo, EN Nicolai, C Alcaino, TJ Cassmann, ST Whiteman, ...
Neurogastroenterology & Motility 32 (12), e13989, 2020
92020
The additional acetylcholine binding site at the α4 (+)/α4 (−) interface of the (α4β2) 2α4 nicotinic acetylcholine receptor contributes to desensitisation
N Benallegue, S Mazzaferro, C Alcaino, I Bermudez
Br J Pharmacol 170, 304-316, 2013
62013
Intestinal enteroendocrine cells rely on ryanodine and IP3 calcium store receptors for mechanotransduction
KR Knutson, ST Whiteman, C Alcaino, A Mercado‐Perez, I Finholm, ...
The Journal of Physiology 601 (2), 287-305, 2023
52023
The fifth subunit of the (α4β2)2β2 nicotinic ACh receptor modulates maximal ACh responses
K New, SG Del Villar, S Mazzaferro, C Alcaino, I Bermudez
British Journal of Pharmacology 175 (11), 1822-1837, 2018
52018
Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
PR Strege, LM Cowan, C Alcaino, A Mazzone, CA Ahern, LS Milescu, ...
Elife 12, e79271, 2023
22023
The mechanosensitive ion channel Piezo2 is selectively expressed in enterochromaffin (EC) cells of the human and mouse gastrointestinal mucosa
K Knutson, F Wang, C Alcaino, C Bernard, G Farrugia, A Beyder
The FASEB Journal 30, 1254.5-1254.5, 2016
22016
The T‐type Voltage Gated Calcium Channel Cav3. 2 is Important for Enteroendocrine Cell Mechanotransduction
K Knutson, C Alcaino, V Nayak, H Kacmaz, AJ Treichel, G Farrugia, ...
The FASEB Journal 33 (S1), 601.4-601.4, 2019
12019
836 THE ENTEROENDOCRINE CELL T-TYPE VOLTAGE GATED CALCIUM CHANNEL CAV3. 2 AFFECTS CELLULAR MECHANOTRANSDUCTION, COLONIC TRANSIT AND VISCERAL HYPERSENSITIVITY
A Mercado-Perez, C Alcaino, KR Knutson, IW Finholm, AJ Wegner, ...
Gastroenterology 164 (6), S-178, 2023
2023
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