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Ivar Roots
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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
S Hoffmeyer, O Burk, O Von Richter, HP Arnold, J Brockmöller, A Johne, ...
Proceedings of the National Academy of Sciences 97 (7), 3473-3478, 2000
33582000
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.
C Sachse, J Brockmöller, S Bauer, I Roots
American journal of human genetics 60 (2), 284, 1997
13511997
Functional significance of a C→ A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
C Sachse, J Brockmöller, S Bauer, I Roots
British journal of clinical pharmacology 47 (4), 445-449, 1999
9541999
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
J Kirchheiner, K Nickchen, M Bauer, ML Wong, J Licinio, I Roots, ...
Molecular psychiatry 9 (5), 442-473, 2004
9512004
Frequency of single nucleotide polymorphisms in the P‐glycoprotein drug transporter MDR1 gene in white subjects
I Cascorbi, T Gerloff, A Johne, C Meisel, S Hoffmeyer, M Schwab, ...
Clinical Pharmacology & Therapeutics 69 (3), 169-174, 2001
9242001
Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
A Johne, J Brockmöller, S Bauer, A Maurer, M Langheinrich, I Roots
Clinical Pharmacology & Therapeutics 66 (4), 338-345, 1999
8061999
CYP2D6 and CYP2C19 genotype‐based dose recommendations for antidepressants: a first step towards subpopulation‐specific dosages
J Kirchheiner, K Brøsen, ML Dahl, LF Gram, S Kasper, I Roots, F Sjöqvist, ...
Acta Psychiatrica Scandinavica 104 (3), 173-192, 2001
5692001
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
J Kirchheiner, H Schmidt, M Tzvetkov, J Keulen, J Lötsch, I Roots, ...
The pharmacogenomics journal 7 (4), 257-265, 2007
5402007
Combined Analysis of Inherited Polymorphisms in Arylamine N-Acetyltransferase 2, Glutathione S-Transferases M1 and T1, Microsomal Epoxide Hydrolase, and …
J Brockmöller, I Cascorbi, R Kerb, I Roots
Cancer Research 56 (17), 3915-3925, 1996
4721996
A C4887A Polymorphism in Exon 7 of Human CYP1A1: Population Frequency, Mutation Linkages, and Impact on Lung Cancer Susceptibility
I Cascorbi, J Brockmöller, I Roots
Cancer research 56 (21), 4965-4969, 1996
4561996
Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population
EA Gaikovitch, I Cascorbi, PM Mrozikiewicz, J Brockmöller, R Frötschl, ...
European journal of clinical pharmacology 59, 303-312, 2003
4462003
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
M Schwab, E Schaeffeler, C Marx, MF Fromm, B Kaskas, J Metzler, ...
Gastroenterology 124 (1), 26-33, 2003
4352003
Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity.
I Cascorbi, N Drakoulis, J Brockmöller, A Maurer, K Sperling, I Roots
American journal of human genetics 57 (3), 581, 1995
4341995
Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein MDR1 gene
A Johne, K Köpke, T Gerloff, I Mai, S Rietbrock, C Meisel, S Hoffmeyer, ...
Clinical Pharmacology & Therapeutics 72 (5), 584-594, 2002
4172002
Critical evaluation of the effect of valerian extract on sleep structure and sleep quality
F Donath, S Quispe, K Diefenbach, A Maurer, I Fietze, I Roots
Pharmacopsychiatry 33 (02), 47-53, 2000
3732000
Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes
AG Hildebrandt, I Roots
Archives of Biochemistry and Biophysics 171 (2), 385-397, 1975
3681975
Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin
S Aynacioglu, J Brockmöller, S Bauer, C Sachse, P Güzelbey, Z Öngen, ...
British journal of clinical pharmacology 48 (3), 409-415, 1999
3561999
Evidence for Inverse Effects of OATP‐C (SLC21A6) *5 and *1b Haplotypes on Pravastatin Kinetics
J Mwinyi, A Johne, S Bauer, I Roots, T Gerloff
Clinical Pharmacology & Therapeutics 75 (5), 415-421, 2004
3432004
Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes
R Kaiser, O Sezer, A Papies, S Bauer, C Schelenz, PB Tremblay, ...
Journal of Clinical Oncology 20 (12), 2805-2811, 2002
3212002
Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6
J Kirchheiner, C Klein, I Meineke, J Sasse, UM Zanger, TE Mürdter, ...
Pharmacogenetics and Genomics 13 (10), 619-626, 2003
3152003
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