| A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation J Datta, K Ghoshal, WA Denny, SA Gamage, DG Brooke, P Phiasivongsa, ... Cancer research 69 (10), 4277-4285, 2009 | 302 | 2009 |
| Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides S Dissanayake, WA Denny, S Gamage, V Sarojini Journal of Controlled Release, 2017 | 270 | 2017 |
| Structure− activity relationships for substituted bis (acridine-4-carboxamides): a new class of anticancer agents SA Gamage, JA Spicer, GJ Atwell, GJ Finlay, BC Baguley, WA Denny Journal of medicinal chemistry 42 (13), 2383-2393, 1999 | 196 | 1999 |
| Structure− activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents SA Gamage, JA Spicer, GW Rewcastle, J Milton, S Sohal, W Dangerfield, ... Journal of medicinal chemistry 45 (3), 740-743, 2002 | 179 | 2002 |
| Structure− activity relationships for the antileishmanial and antitrypanosomal activities of 1 ‘-substituted 9-anilinoacridines SA Gamage, DP Figgitt, SJ Wojcik, RK Ralph, A Ransijn, J Mauel, ... Journal of medicinal chemistry 40 (16), 2634-2642, 1997 | 157 | 1997 |
| Structure− activity relationships of 1, 2, 4-benzotriazine 1, 4-dioxides as hypoxia-selective analogues of tirapazamine MP Hay, SA Gamage, MS Kovacs, FB Pruijn, RF Anderson, AV Patterson, ... Journal of medicinal chemistry 46 (1), 169-182, 2003 | 139 | 2003 |
| Synthesis and in vitro evaluation of 9-anilino-3, 6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum SA Gamage, N Tepsiri, P Wilairat, SJ Wojcik, DP Figgitt, RK Ralph, ... Journal of medicinal chemistry 37 (10), 1486-1494, 1994 | 136 | 1994 |
| Activation of 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents to oxidizing species following their one-electron reduction RF Anderson, SS Shinde, MP Hay, SA Gamage, WA Denny Journal of the American Chemical Society 125 (3), 748-756, 2003 | 130 | 2003 |
| Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4, 6-di (4-morpholinyl)-1, 3, 5 … GW Rewcastle, SA Gamage, JU Flanagan, R Frederick, WA Denny, ... Journal of medicinal chemistry 54 (20), 7105-7126, 2011 | 118 | 2011 |
| Bis (phenazine-1-carboxamides): structure− activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs JA Spicer, SA Gamage, GW Rewcastle, GJ Finlay, DJA Bridewell, ... Journal of medicinal chemistry 43 (7), 1350-1358, 2000 | 112 | 2000 |
| Structure−Activity Relationships for Acridine-Substituted Analogues of the Mixed Topoisomerase I/II Inhibitor N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide JA Spicer, SA Gamage, GJ Atwell, GJ Finlay, BC Baguley, WA Denny Journal of medicinal chemistry 40 (12), 1919-1929, 1997 | 108 | 1997 |
| DNA-targeted 1, 2, 4-benzotriazine 1, 4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine MP Hay, FB Pruijn, SA Gamage, HDS Liyanage, MS Kovacs, ... Journal of medicinal chemistry 47 (2), 475-488, 2004 | 102 | 2004 |
| Crystal structure of the pyocyanin biosynthetic protein PhzS BT Greenhagen, K Shi, H Robinson, S Gamage, AK Bera, JE Ladner, ... Biochemistry 47 (19), 5281-5289, 2008 | 95 | 2008 |
| Dicationic bis (9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer … SA Gamage, JA Spicer, GJ Finlay, AJ Stewart, P Charlton, BC Baguley, ... Journal of medicinal chemistry 44 (9), 1407-1415, 2001 | 89 | 2001 |
| Structure-activity relationships and modes of action of 9-anilinoacridines against chloroquine-resistant Plasmodium falciparum in vitro. P Chavalitshewinkoon, P Wilairat, S Gamage, W Denny, D Figgitt, ... Antimicrobial agents and chemotherapy 37 (3), 403-406, 1993 | 87 | 1993 |
| Quinoline derivatives for modulating DNA methylation P Phiasivongsa, SG Redkar, S Gamage, D Brooke, W Denny, DJ Bearss, ... US Patent 7,939,546, 2011 | 81 | 2011 |
| Quinoline derivatives for modulating dna methylation P Phiasivongsa, SG Redkar, S Gamage, D Brooke, W Denny, DJ Bearss, ... US Patent App. 13/047,635, 2011 | 57 | 2011 |
| Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1, 2, 4-benzotriazine 1, 4-dioxides SS Shinde, RF Anderson, MP Hay, SA Gamage, WA Denny Journal of the American Chemical Society 126 (25), 7865-7874, 2004 | 52 | 2004 |
| Quinoline derivatives for modulating dna methylation P Phiasivongsa, SG Redkar, S Gamage, D Brooke, W Denny, DJ Bearss, ... US Patent App. 12/556,510, 2009 | 51 | 2009 |
| Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1, 2, 4-benzotriazine 1, 4-dioxides RF Anderson, SS Shinde, MP Hay, SA Gamage, WA Denny Organic & biomolecular chemistry 3 (11), 2167-2174, 2005 | 41 | 2005 |
