| DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks A Mosbech, I Gibbs-Seymour, K Kagias, T Thorslund, P Beli, L Povlsen, ... Nature structural & molecular biology 19 (11), 1084-1092, 2012 | 215 | 2012 |
| Molecular basis and regulation of OTULIN-LUBAC interaction PR Elliott, SV Nielsen, P Marco-Casanova, BK Fiil, K Keusekotten, ... Molecular cell 54 (3), 335-348, 2014 | 200 | 2014 |
| Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations SV Nielsen, A Stein, AB Dinitzen, E Papaleo, MH Tatham, EG Poulsen, ... PLoS genetics 13 (4), e1006739, 2017 | 92 | 2017 |
| Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance M Cagiada, KE Johansson, A Valanciute, SV Nielsen, ... Molecular Biology and Evolution 38 (8), 3235-3246, 2021 | 70 | 2021 |
| A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability F Kriegenburg, V Jakopec, EG Poulsen, SV Nielsen, A Roguev, N Krogan, ... PLoS genetics 10 (1), e1004140, 2014 | 66 | 2014 |
| Towards mechanistic models for genotype‐phenotype correlations in phenylketonuria using protein stability calculations R Scheller, A Stein, SV Nielsen, FI Marin, AM Gerdes, MD Marco, ... Human Mutation, 2019 | 60 | 2019 |
| Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome AB Abildgaard, A Stein, SV Nielsen, K Schultz-Knudsen, E Papaleo, ... Elife 8, e49138, 2019 | 48 | 2019 |
| Protein quality control in the nucleus SV Nielsen, EG Poulsen, CA Rebula, R Hartmann-Petersen Biomolecules 4 (3), 646-661, 2014 | 44 | 2014 |
| Co-chaperones in targeting and delivery of misfolded proteins to the 26S proteasome AB Abildgaard, SK Gersing, S Larsen-Ledet, SV Nielsen, A Stein, ... Biomolecules 10 (8), 1141, 2020 | 36 | 2020 |
| Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases W Boomsma, SV Nielsen, K Lindorff-Larsen, R Hartmann-Petersen, ... PeerJ 4, e1725, 2016 | 30 | 2016 |
| Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation L Clausen, A Stein, M Grønbæk-Thygesen, L Nygaard, CL Søltoft, ... PLoS genetics 16 (11), e1009187, 2020 | 24 | 2020 |
| Lynch syndrome, molecular mechanisms and variant classification AB Abildgaard, SV Nielsen, I Bernstein, A Stein, K Lindorff-Larsen, ... British journal of cancer 128 (5), 726-734, 2023 | 23 | 2023 |
| Blocking protein quality control to counter hereditary cancers C Kampmeyer, SV Nielsen, L Clausen, A Stein, AM Gerdes, ... Genes, Chromosomes and Cancer 56 (12), 823-831, 2017 | 23 | 2017 |
| Disease-linked mutations cause exposure of a protein quality control degron C Kampmeyer, S Larsen-Ledet, MR Wagnkilde, M Michelsen, ... Structure 30 (9), 1245-1253. e5, 2022 | 17 | 2022 |
| Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect L Madsen, K Molbæk, IB Larsen, SV Nielsen, EG Poulsen, PS Walmod, ... BMC cell biology 15, 1-10, 2014 | 13 | 2014 |
| Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition SV Nielsen, R Hartmann-Petersen, A Stein, K Lindorff-Larsen PLoS Genetics 17 (4), e1009496, 2021 | 12 | 2021 |
| Protein destabilization and degradation as a mechanism for hereditary disease SV Nielsen, SM Schenstrøm, CE Christensen, A Stein, K Lindorff-Larsen, ... Protein homeostasis diseases, 111-125, 2020 | 3 | 2020 |
| High-Throughput siRNA Screening Applied to the Ubiquitin–Proteasome System EG Poulsen, SV Nielsen, EJ Pietras, JV Johansen, C Steinhauer, ... Proteostasis: Methods and Protocols, 421-439, 2016 | 3 | 2016 |
| Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein C Kampmeyer, S Larsen-Ledet, MR Wagnkilde, M Michelsen, ... bioRxiv, 2021.11. 04.467226, 2021 | 2 | 2021 |
| Structural destabilization and chaperone-assisted proteasomal degradation of MLH1 as a mechanism for Lynch syndrome AB Abildgaard, A Stein, K Schultz-Knudsen, SV Nielsen, E Papaleo, ... BioRxiv, 622266, 2019 | 1 | 2019 |
Kresten Lindorff-LarsenLinderstrøm-Lang Centre for Protein Science, Department of Biology, University of CopenhagenVerified email at bio.ku.dk
