| Discovery of taniborbactam (VNRX-5133): a broad-spectrum serine-and metallo-β-lactamase inhibitor for carbapenem-resistant bacterial infections B Liu, REL Trout, GH Chu, D McGarry, RW Jackson, JC Hamrick, ... Journal of Medicinal Chemistry 63 (6), 2789-2801, 2019 | 250 | 2019 |
| VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and … JC Hamrick, JD Docquier, T Uehara, CL Myers, DA Six, CL Chatwin, ... Antimicrobial Agents and Chemotherapy 64 (3), 10.1128/aac. 01963-19, 2020 | 175 | 2020 |
| mexEF-oprN Multidrug Efflux Operon of Pseudomonas aeruginosa: Regulation by the MexT Activator in Response to Nitrosative Stress and Chloramphenicol H Fetar, C Gilmour, R Klinoski, DM Daigle, CR Dean, K Poole Antimicrobial agents and chemotherapy 55 (2), 508-514, 2011 | 156 | 2011 |
| Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors DM Daigle, GA McKay, GD Wright Journal of Biological Chemistry 272 (40), 24755-24758, 1997 | 134 | 1997 |
| Studies of the Interaction of Escherichia coli YjeQ with the Ribosome In Vitro DM Daigle, ED Brown Journal of bacteriology 186 (5), 1381-1387, 2004 | 133 | 2004 |
| Prodigious substrate specificity of AAC (6′)-APH (2′'), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci DM Daigle, DW Hughes, GD Wright Chemistry & biology 6 (2), 99-110, 1999 | 131 | 1999 |
| Aminoglycoside antibiotic phosphotransferases are also serine protein kinases DM Daigle, GA McKay, PR Thompson, GD Wright Chemistry & biology 6 (1), 11-18, 1999 | 114 | 1999 |
| Beta-lactamase inhibitors CJ Burns, D Daigle, B Liu, D McGarry, DC Pevear, REL TROUT, ... US Patent 9,040,504, 2015 | 106 | 2015 |
| Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility X Li, M Zolli-Juran, JD Cechetto, DM Daigle, GD Wright, ED Brown Chemistry & biology 11 (10), 1423-1430, 2004 | 103 | 2004 |
| YjeQ, an Essential, Conserved, Uncharacterized Protein from Escherichia coli, Is an Unusual GTPase with Circularly Permuted G-Motifs and Marked Burst Kinetics DM Daigle, L Rossi, AM Berghuis, L Aravind, EV Koonin, ED Brown Biochemistry 41 (37), 11109-11117, 2002 | 95 | 2002 |
| High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate M Zolli-Juran, JD Cechetto, R Hartlen, DM Daigle, ED Brown Bioorganic & medicinal chemistry letters 13 (15), 2493-2496, 2003 | 90 | 2003 |
| Protein Modulator of Multidrug Efflux Gene Expression in Pseudomonas aeruginosa DM Daigle, L Cao, S Fraud, MS Wilke, A Pacey, R Klinoski, NC Strynadka, ... Journal of bacteriology 189 (15), 5441-5451, 2007 | 83 | 2007 |
| Domain− Domain Interactions in the Aminoglycoside Antibiotic Resistance Enzyme AAC (6 ‘)-APH (2 ‘‘) DD Boehr, DM Daigle, GD Wright Biochemistry 43 (30), 9846-9855, 2004 | 76 | 2004 |
| Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function TL Campbell, DM Daigle, ED Brown Biochemical Journal 389 (3), 843-852, 2005 | 71 | 2005 |
| Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415 CR Dean, S Narayan, DM Daigle, JAL Dzink-Fox, X Puyang, KR Bracken, ... Antimicrobial agents and chemotherapy 49 (8), 3129-3135, 2005 | 56 | 2005 |
| An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase S Mayer, DM Daigle, ED Brown, J Khatri, MG Organ Journal of combinatorial chemistry 6 (5), 776-782, 2004 | 54 | 2004 |
| Beta-lactamase inhibitors CJ Burns, D Daigle, B Liu, D McGarry, DC Pevear, REL TROUT US Patent 9,511,142, 2016 | 53 | 2016 |
| A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region RL Summerfield, DM Daigle, S Mayer, D Mallik, DW Hughes, SG Jackson, ... Journal of medicinal chemistry 49 (24), 6977-6986, 2006 | 50 | 2006 |
| Fmt Bypass in Pseudomonas aeruginosa Causes Induction of MexXY Efflux Pump Expression RE Caughlan, S Sriram, DM Daigle, AL Woods, J Buco, RL Peterson, ... Antimicrobial agents and chemotherapy 53 (12), 5015-5021, 2009 | 48 | 2009 |
| Beta-lactamase inhibitors CJ Burns, D Daigle, B Liu, D Mcgarry, DC Pevear, REL TROUT | 39 | 2014 |
