Michael P Murphy
Michael P Murphy
MRC Mitochondrial BIology Unit, University of Cambridge
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How mitochondria produce reactive oxygen species
MP Murphy
Biochemical journal 417 (1), 1-13, 2009
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
ET Chouchani, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, ...
Nature 515 (7527), 431-435, 2014
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ...
Cell 167 (2), 457-470. e13, 2016
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113-117, 2018
Targeting antioxidants to mitochondria by conjugation to lipophilic cations
MP Murphy, RAJ Smith
Annu. Rev. Pharmacol. Toxicol. 47, 629-656, 2007
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties
GF Kelso, CM Porteous, CV Coulter, G Hughes, WK Porteous, ...
Journal of Biological Chemistry 276 (7), 4588-4596, 2001
Unraveling the biological roles of reactive oxygen species
MP Murphy, A Holmgren, NG Larsson, B Halliwell, CJ Chang, ...
Cell metabolism 13 (4), 361-366, 2011
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
KM Robinson, MS Janes, M Pehar, JS Monette, MF Ross, TM Hagen, ...
Proceedings of the National Academy of Sciences 103 (41), 15038-15043, 2006
Delivery of bioactive molecules to mitochondria in vivo
RAJ Smith, CM Porteous, AM Gane, MP Murphy
Proceedings of the National Academy of Sciences 100 (9), 5407-5412, 2003
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
K Green, MD Brand, MP Murphy
Diabetes 53 (suppl_1), S110-S118, 2004
Targeting an antioxidant to mitochondria decreases cardiac ischemia‐reperfusion injury
VJ Adlam, JC Harrison, CM Porteous, AM James, RAJ Smith, MP Murphy, ...
The FASEB Journal 19 (9), 1088-1095, 2005
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury
ET Chouchani, VR Pell, AM James, LM Work, K Saeb-Parsy, C Frezza, ...
Cell metabolism 23 (2), 254-263, 2016
Complex I is the major site of mitochondrial superoxide production by paraquat
HM Cochemé, MP Murphy
Journal of biological chemistry 283 (4), 1786-1798, 2008
Redox homeostasis and mitochondrial dynamics
PHGM Willems, R Rossignol, CEJ Dieteren, MP Murphy, WJH Koopman
Cell metabolism 22 (2), 207-218, 2015
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
EL Bell, TA Klimova, J Eisenbart, CT Moraes, MP Murphy, GRS Budinger, ...
The Journal of cell biology 177 (6), 1029-1036, 2007
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
H Sies, VV Belousov, NS Chandel, MJ Davies, DP Jones, GE Mann, ...
Nature Reviews Molecular Cell Biology 23 (7), 499-515, 2022
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
ET Chouchani, C Methner, SM Nadtochiy, A Logan, VR Pell, S Ding, ...
Nature medicine 19 (6), 753-759, 2013
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
V Tarallo, Y Hirano, BD Gelfand, S Dridi, N Kerur, Y Kim, WG Cho, ...
Cell 149 (4), 847-859, 2012
Mitochondria as a therapeutic target for common pathologies
MP Murphy, RC Hartley
Nature Reviews Drug Discovery 17 (12), 865-886, 2018
Targeting lipophilic cations to mitochondria
MP Murphy
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1777 (7-8), 1028-1031, 2008
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