| Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics F Mohamadi, NGJ Richards, WC Guida, R Liskamp, M Lipton, C Caufield, ... Journal of Computational Chemistry 11 (4), 440-467, 1990 | 4057 | 1990 |
| The art and practice of structure‐based drug design: a molecular modeling perspective RS Bohacek, C McMartin, WC Guida Medicinal research reviews 16 (1), 3-50, 1996 | 1481 | 1996 |
| An internal-coordinate Monte Carlo method for searching conformational space G Chang, WC Guida, WC Still Journal of the American Chemical Society 111 (12), 4379-4386, 1989 | 1479 | 1989 |
| Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity K Siddiquee, S Zhang, WC Guida, MA Blaskovich, B Greedy, ... Proceedings of the National Academy of Sciences 104 (18), 7391-7396, 2007 | 887 | 2007 |
| Conformations of cycloheptadecane. A comparison of methods for conformational searching M Saunders, KN Houk, YD Wu, WC Still, M Lipton, G Chang, WC Guida Journal of the American Chemical Society 112 (4), 1419-1427, 1990 | 733 | 1990 |
| Low mode search. An efficient, automated computational method for conformational analysis: application to cyclic and acyclic alkanes and cyclic peptides I Kolossváry, WC Guida Journal of the American Chemical Society 118 (21), 5011-5019, 1996 | 504 | 1996 |
| Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells KG Daniel, P Gupta, RH Harbach, WC Guida, QP Dou Biochemical pharmacology 67 (6), 1139-1151, 2004 | 360 | 2004 |
| Discovery of a novel shp2 protein tyrosine phosphatase inhibitor L Chen, SS Sung, MLR Yip, HR Lawrence, Y Ren, WC Guida, SM Sebti, ... Molecular pharmacology 70 (2), 562-570, 2006 | 331 | 2006 |
| Accurate prediction of acidity constants in aqueous solution via density functional theory and self-consistent reaction field methods JJ Klicić, RA Friesner, SY Liu, WC Guida The Journal of Physical Chemistry A 106 (7), 1327-1335, 2002 | 303 | 2002 |
| Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors. SE Ealick, YS Babu, CE Bugg, MD Erion, WC Guida, JA Montgomery, ... Proceedings of the National Academy of Sciences 88 (24), 11540-11544, 1991 | 235 | 1991 |
| Low‐mode conformational search elucidated: Application to C39H80 and flexible docking of 9‐deazaguanine inhibitors into PNP I Kolossváry, WC Guida Journal of Computational Chemistry 20 (15), 1671-1684, 1999 | 226 | 1999 |
| Copper storage diseases: Menkes, Wilsons, and cancer KG Daniel, RH Harbach, WC Guida, QP Dou Front Biosci 9, 2652-2662, 2004 | 185 | 2004 |
| Purine nucleoside phosphorylase. 2. Catalytic mechanism MD Erion, JD Stoeckler, WC Guida, RL Walter, SE Ealick Biochemistry 36 (39), 11735-11748, 1997 | 183 | 1997 |
| Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX J Phan, Z Li, A Kasprzak, B Li, S Sebti, W Guida, E Schönbrunn, J Chen Journal of biological chemistry 285 (3), 2174-2183, 2010 | 175 | 2010 |
| Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine JA Montgomery, S Niwas, JD Rose, JA Secrist III, YS Babu, CE Bugg, ... Journal of medicinal chemistry 36 (1), 55-69, 1993 | 168 | 1993 |
| MacroModel V5. 5 N Richards, W Guida, R Liskamp, M Lipton, C Canfield, G Chang, ... J. Comput. Chem 11, 440, 1990 | 168 | 1990 |
| Phase-transfer alkylation of heterocycles in the presence of 18-crown-6 and potassium tert-butoxide WC Guida, DJ Mathre The Journal of Organic Chemistry 45 (16), 3172-3176, 1980 | 153 | 1980 |
| A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation X Zhang, Y Sun, R Pireddu, H Yang, MK Urlam, HR Lawrence, WC Guida, ... Cancer research 73 (6), 1922-1933, 2013 | 150 | 2013 |
| Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design DM Smith, KG Daniel, Z Wang, WC Guida, TH Chan, QP Dou Proteins: Structure, Function, and Bioinformatics 54 (1), 58-70, 2004 | 148 | 2004 |
| Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics F Mohamdi, NGJ Richards, WC Guida, R Liskamp, M Lipton, C Caufield, ... J. Comput. Chem 11, 440-467, 1990 | 143 | 1990 |
