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Svetlana Kholodar
Svetlana Kholodar
Scientist at Frontier Medicines
Verified email at frontiermeds.com
Title
Cited by
Cited by
Year
Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase
AS Murkin, KA Manning, SA Kholodar
Bioorganic Chemistry 57, 171-185, 2014
462014
Covalent modification and regulation of the nuclear receptor Nurr1 by a dopamine metabolite
JM Bruning, Y Wang, F Oltrabella, B Tian, SA Kholodar, H Liu, ...
Cell chemical biology 26 (5), 674-685. e6, 2019
432019
DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group
SA Kholodar, AS Murkin
Biochemistry 52 (13), 2302-2308, 2013
242013
The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces
SA Kholodar, CL Allen, AM Gulick, AS Murkin
Journal of the American Chemical Society 137 (7), 2748-2756, 2015
222015
Measurement of enzyme isotope effects
SA Kholodar, AK Ghosh, A Kohen
Methods in Enzymology 596, 43-83, 2017
212017
Oligo(2′-O-methylribonucleotides) and their derivatives: III. 5′-Mono- and 5′-bispyrenyl derivatives of oligo(2′-O-methylribonucleotides) and their 3 …
DS Novopashina, OS Totskaya, SA Kholodar’, MI Meshchaninova, ...
Russian Journal of Bioorganic Chemistry 34, 602-612, 2008
192008
Noncovalent intermediate of thymidylate synthase: Fact or fiction?
SA Kholodar, A Kohen
Journal of the American Chemical Society 138 (26), 8056-8059, 2016
172016
Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin
SA Kholodar, G Tombline, J Liu, Z Tan, CL Allen, AM Gulick, AS Murkin
Biochemistry 53 (21), 3423-3431, 2014
132014
Analogs of the dopamine metabolite 5, 6-dihydroxyindole bind directly to and activate the nuclear receptor Nurr1
SA Kholodar, G Lang, WA Cortopassi, Y Iizuka, HS Brah, MP Jacobson, ...
ACS chemical biology 16 (7), 1159-1163, 2021
112021
Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools
SA Kholodar, AK Ghosh, K Świderek, V Moliner, A Kohen
Proceedings of the National Academy of Sciences 115 (41), 10311-10314, 2018
92018
Multipyrene tandem probes for detection of C677T polymorphism in MTHFR gene
SA Kholodar, DS Novopashina, MI Meschaninova, AA Lomzov, ...
Nucleic Acids Symposium Series 53 (1), 143-144, 2009
52009
New eximer-based tandem systems for SNP detection
DS Novopashina, MI Meschaninova, SA Kholodar, AA Lomzov, ...
Nucleic Acids Symposium Series 52 (1), 229-230, 2008
52008
Multipyrene tandem probes for point mutations detection in DNA
SA Kholodar, DS Novopashina, MI Meschaninova, AG Venyaminova
Journal of Nucleic Acids 2013, 2013
42013
Caught in action: X-ray structure of thymidylate synthase with noncovalent intermediate analog
SA Kholodar, JS Finer-Moore, K Swiderek, K Arafet, V Moliner, RM Stroud, ...
Biochemistry 60 (16), 1243-1247, 2021
12021
Isolation and characterization of a novel intermediate of thymidylate synthase: Possibility of a new class of chemotherapeutic drugs targeting thymidylate synthase
AK Ghosh, SA Kholodar, A Kohen
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018
2018
QM/MM computations and experimental studies reveals an unexpected intermediate in thymidylate synthase catalysis
S Kholodar, V Moliner, A Kohen
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254, 2017
2017
Tandems of pyrene-labeled oligo (2'-O-methylribonucleotides) for SNP detection
D Novopashina, M Meschaninova, S Kholodar, A Venyaminova
Collection of Czechoslovak Chemical Communications 10, 417-419, 2015
2015
The method for synthesis of new bifunctional conjugates of oligonucleotides
D Novopashina, S Kholodar, A Venyaminova
Collection of Czechoslovak Chemical Communications 12, 413-415, 2015
2015
The role of phosphate in a multistep enzymatic reaction
SA Kholodar
State University of New York at Buffalo, 2015
2015
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Articles 1–19