| Oligonucleotides containing 5-fluorouracil WH Gmeiner, PL Iversen US Patent 5,457,187, 1995 | 658 | 1995 |
| Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes S Ghosh, S Dutta, E Gomes, D Carroll, R D’Agostino Jr, J Olson, ... ACS nano 3 (9), 2667-2673, 2009 | 288 | 2009 |
| Nanotechnology for cancer treatment WH Gmeiner, S Ghosh Nanotechnology reviews 3 (2), 111-122, 2014 | 226 | 2014 |
| Unfolding of G-quadruplexes: energetic, and ion and water contributions of G-quartet stacking CM Olsen, WH Gmeiner, LA Marky The Journal of Physical Chemistry B 110 (13), 6962-6969, 2006 | 152 | 2006 |
| Gemcitabine (2′, 2′-difluoro-2′-deoxycytidine), an antimetabolite that poisons topoisomerase I P Pourquier, C Gioffre, G Kohlhagen, Y Urasaki, F Goldwasser, LW Hertel, ... Clinical Cancer Research 8 (8), 2499-2504, 2002 | 141 | 2002 |
| Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP [10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells J Liu, C Kolar, TA Lawson, WH Gmeiner The Journal of Organic Chemistry 66 (17), 5655-5663, 2001 | 116 | 2001 |
| Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry JR Engen, TE Smithgall, WH Gmeiner, DL Smith Biochemistry 36 (47), 14384-14391, 1997 | 112 | 1997 |
| Novel chemical strategies for thymidylate synthase inhibition WH Gmeiner Current medicinal chemistry 12 (2), 191-202, 2005 | 101 | 2005 |
| TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs SN Huang, J Murai, I Dalla Rosa, TS Dexheimer, A Naumova, ... Nucleic acids research 41 (16), 7793-7803, 2013 | 99 | 2013 |
| Dimeric DNA aptamer complexes for high-capacity–targeted drug delivery using pH-sensitive covalent linkages O Boyacioglu, CH Stuart, G Kulik, WH Gmeiner Molecular Therapy-Nucleic Acids 2, 2013 | 96 | 2013 |
| Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP [10] with fluorouracil, floxuridine, and topoisomerase 1 poisons WH Gmeiner, WC Reinhold, Y Pommier Molecular cancer therapeutics 9 (12), 3105-3114, 2010 | 91 | 2010 |
| Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2 JR Engen, WH Gmeiner, TE Smithgall, DL Smith Biochemistry 38 (28), 8926-8935, 1999 | 89 | 1999 |
| NMR Structure of the Thrombin-Binding DNA Aptamer Stabilized by Sr2+ X Mao, LA Marky, WH Gmeiner Journal of Biomolecular Structure and Dynamics 22 (1), 25-33, 2004 | 67 | 2004 |
| Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment JR McCONNELL, S Swindells, CS Ong, WH Gmeiner, WEIKOM CHU, ... AIDS research and human retroviruses 10 (8), 977-982, 1994 | 67 | 1994 |
| A novel polypyrimidine antitumor agent FdUMP [10] induces thymineless death with topoisomerase I-DNA complexes ZY Liao, O Sordet, HL Zhang, G Kohlhagen, S Antony, WH Gmeiner, ... Cancer research 65 (11), 4844-4851, 2005 | 62 | 2005 |
| Implications of SH3 domain structure and dynamics for protein regulation and drug design WH Gmeiner, DA Horita Cell biochemistry and biophysics 35, 127-140, 2001 | 56 | 2001 |
| Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells C Mani, S Jonnalagadda, J Lingareddy, S Awasthi, WH Gmeiner, K Palle Breast Cancer Research 21, 1-14, 2019 | 54 | 2019 |
| NMR study of the folding–unfolding mechanism for the thrombin-binding DNA aptamer d (GGTTGGTGTGGTTGG) X Mao, WH Gmeiner Biophysical chemistry 113 (2), 155-160, 2005 | 51 | 2005 |
| Increased cytotoxicity and decreased in vivo toxicity of FdUMP [10] relative to 5-FU J Liu, A Skradis, C Kolar, J Kolath, J Anderson, T Lawson, J Talmadge, ... Nucleosides & nucleotides 18 (8), 1789-1802, 1999 | 45 | 1999 |
| Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP [10] results in high efficacy against AML and low toxicity TS Pardee, E Gomes, J Jennings-Gee, D Caudell, WH Gmeiner Blood, The Journal of the American Society of Hematology 119 (15), 3561-3570, 2012 | 44 | 2012 |
