Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes PS Coelho, EM Brustad, A Kannan, FH Arnold Science 339 (6117), 307-310, 2013 | 878 | 2013 |
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo PS Coelho, ZJ Wang, ME Ener, SA Baril, A Kannan, FH Arnold, ... Nature chemical biology 9 (8), 485-487, 2013 | 369 | 2013 |
Site-directed spin labeling of a genetically encoded unnatural amino acid MR Fleissner, EM Brustad, T Kálai, C Altenbach, D Cascio, FB Peters, ... Proceedings of the National Academy of Sciences 106 (51), 21637-21642, 2009 | 298 | 2009 |
Optimizing non-natural protein function with directed evolution EM Brustad, FH Arnold Current opinion in chemical biology 15 (2), 201-210, 2011 | 295 | 2011 |
A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer EM Brustad, EA Lemke, PG Schultz, AA Deniz Journal of the American Chemical Society 130 (52), 17664-17665, 2008 | 239 | 2008 |
A genetically encoded boronate amino acid E Brustad, ML Bushey, JW Lee, D Groff, W Liu, PG Schultz Angewandte Chemie (International ed. in English) 47 (43), 8220, 2008 | 230 | 2008 |
The Incorporation of a Photoisomerizable Amino Acid into Proteins in E. c oli M Bose, D Groff, J Xie, E Brustad, PG Schultz Journal of the American Chemical Society 128 (2), 388-389, 2006 | 227 | 2006 |
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH S Brinkmann-Chen, T Flock, JKB Cahn, CD Snow, EM Brustad, ... Proceedings of the National Academy of Sciences 110 (27), 10946-10951, 2013 | 129 | 2013 |
Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity VS Lelyveld, E Brustad, FH Arnold, A Jasanoff Journal of the American Chemical Society 133 (4), 649-651, 2011 | 100 | 2011 |
Active targeting of cancer cells by nanobody decorated polypeptide micelle with bio-orthogonally conjugated drug SA Costa, D Mozhdehi, MJ Dzuricky, FJ Isaacs, EM Brustad, A Chilkoti Nano letters 19 (1), 247-254, 2018 | 93 | 2018 |
Evolution of proteins with genetically encoded “chemical warheads” CC Liu, AV Mack, EM Brustad, JH Mills, D Groff, VV Smider, PG Schultz Journal of the American Chemical Society 131 (28), 9616-9617, 2009 | 92 | 2009 |
Genetically encoded alkenes in yeast H Ai, W Shen, E Brustad, PG Schultz Angewandte Chemie 122 (5), 947-949, 2010 | 86 | 2010 |
Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin CC Liu, E Brustad, W Liu, PG Schultz Journal of the American Chemical Society 129 (35), 10648-10649, 2007 | 82 | 2007 |
Osmolytes and protein–protein interactions AE Rydeen, EM Brustad, GJ Pielak Journal of the American Chemical Society 140 (24), 7441-7444, 2018 | 79 | 2018 |
Mutating a highly conserved residue in diverse cytochrome P450s facilitates diastereoselective olefin cyclopropanation JG Gober, AE Rydeen, EJ Gibson‐O'Grady, JB Leuthaeuser, JS Fetrow, ... ChemBioChem 17 (5), 394-397, 2016 | 77 | 2016 |
Microfluidic device for single-molecule experiments with enhanced photostability EA Lemke, Y Gambin, V Vandelinder, EM Brustad, HW Liu, PG Schultz, ... Journal of the American Chemical Society 131 (38), 13610-13612, 2009 | 76 | 2009 |
Photo‐crosslinkable unnatural amino acids enable facile synthesis of thermoresponsive nano‐to microgels of intrinsically disordered polypeptides SA Costa, JR Simon, M Amiram, L Tang, S Zauscher, EM Brustad, ... Advanced Materials 30 (5), 1704878, 2018 | 75 | 2018 |
P450-mediated non-natural cyclopropanation of dehydroalanine-containing thiopeptides JG Gober, SV Ghodge, JW Bogart, WJ Wever, RR Watkins, EM Brustad, ... ACS Chemical Biology 12 (7), 1726-1731, 2017 | 73 | 2017 |
Subcellular protein localization by using a genetically encoded fluorescent amino acid G Charbon, E Brustad, KA Scott, J Wang, A Lřbner-Olesen, PG Schultz, ... ChemBioChem 12 (12), 1818, 2011 | 57 | 2011 |
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins E Brustad, ML Bushey, A Brock, J Chittuluru, PG Schultz Bioorganic & medicinal chemistry letters 18 (22), 6004-6006, 2008 | 57 | 2008 |