| Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity JGM Markle, DN Frank, S Mortin-Toth, CE Robertson, LM Feazel, ... Science 339 (6123), 1084-1088, 2013 | 1900 | 2013 |
| Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations S Okada, JG Markle, EK Deenick, F Mele, D Averbuch, M Lagos, ... Science 349 (6248), 606-613, 2015 | 417 | 2015 |
| SeXX matters in immunity JG Markle, EN Fish Trends in immunology 35 (3), 97-104, 2014 | 367 | 2014 |
| Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor–null mice with diet-induced insulin resistance EE Mulvihill, EM Allister, BG Sutherland, DE Telford, CG Sawyez, ... Diabetes 58 (10), 2198-2210, 2009 | 348 | 2009 |
| The mutation significance cutoff: gene-level thresholds for variant predictions Y Itan, L Shang, B Boisson, MJ Ciancanelli, JG Markle, ... Nature methods 13 (2), 109-110, 2016 | 292 | 2016 |
| The human gene damage index as a gene-level approach to prioritizing exome variants Y Itan, L Shang, B Boisson, E Patin, A Bolze, M Moncada-Vélez, E Scott, ... Proceedings of the National Academy of Sciences 112 (44), 13615-13620, 2015 | 243 | 2015 |
| Mendelian susceptibility to mycobacterial disease: 2014–2018 update J Rosain, XF Kong, R Martinez‐Barricarte, C Oleaga‐Quintas, ... Immunology and cell biology 97 (4), 360-367, 2019 | 187 | 2019 |
| Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23 R Martínez-Barricarte, JG Markle, CS Ma, EK Deenick, N Ramírez-Alejo, ... Science immunology 3 (30), eaau6759, 2018 | 172 | 2018 |
| Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant S Boisson-Dupuis, N Ramirez-Alejo, Z Li, E Patin, G Rao, G Kerner, ... Science immunology 3 (30), eaau8714, 2018 | 168 | 2018 |
| Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24 (S), 25-epoxycholesterol MM Beyea, CL Heslop, CG Sawyez, JY Edwards, JG Markle, RA Hegele, ... Journal of Biological Chemistry 282 (8), 5207-5216, 2007 | 139 | 2007 |
| The human CIB1–EVER1–EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses SJ De Jong, A Créquer, I Matos, D Hum, V Gunasekharan, L Lorenzo, ... Journal of Experimental Medicine 215 (9), 2289-2310, 2018 | 102 | 2018 |
| Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria R Yang, F Mele, L Worley, D Langlais, J Rosain, I Benhsaien, H Elarabi, ... Cell 183 (7), 1826-1847. e31, 2020 | 101 | 2020 |
| Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency XF Kong, R Martinez-Barricarte, J Kennedy, F Mele, T Lazarov, ... Nature immunology 19 (9), 973-985, 2018 | 96 | 2018 |
| γδ T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model JGM Markle, S Mortin-Toth, ASL Wong, L Geng, A Hayday, JS Danska The Journal of Immunology 190 (11), 5392-5401, 2013 | 78 | 2013 |
| Microbiome manipulation modifies sex-specific risk for autoimmunity JGM Markle, DN Frank, K Adeli, M Von Bergen, JS Danska Gut microbes 5 (4), 485-493, 2014 | 76 | 2014 |
| Generation and analysis of a mouse intestinal metatranscriptome through Illumina based RNA-sequencing X Xiong, DN Frank, CE Robertson, SS Hung, J Markle, AJ Canty, ... PloS one 7 (4), e36009, 2012 | 68 | 2012 |
| Comparison of assembly algorithms for improving rate of metatranscriptomic functional annotation A Celaj, J Markle, J Danska, J Parkinson Microbiome 2, 1-13, 2014 | 58 | 2014 |
| IRF4 haploinsufficiency in a family with Whipple’s disease A Guérin, G Kerner, N Marr, JG Markle, F Fenollar, N Wong, S Boughorbel, ... Elife 7, e32340, 2018 | 57 | 2018 |
| KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy‐lysosome defect KA Metz, X Teng, I Coppens, HM Lamb, BE Wagner, JA Rosenfeld, ... Annals of neurology 84 (5), 766-780, 2018 | 47 | 2018 |
| Visceral leishmaniasis in two patients with IL‐12p40 and IL‐12Rβ1 deficiencies N Parvaneh, V Barlogis, A Alborzi, C Deswarte, S Boisson‐Dupuis, ... Pediatric blood & cancer 64 (6), e26362, 2017 | 30 | 2017 |
