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Charlotte M. Miton
Charlotte M. Miton
Verified email at msl.ubc.ca - Homepage
Title
Cited by
Cited by
Year
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics
PY Colin, B Kintses, F Gielen, CM Miton, G Fischer, MF Mohamed, ...
Nature communications 6 (1), 10008, 2015
3902015
How mutational epistasis impairs predictability in protein evolution and design
CM Miton, N Tokuriki
Protein Science 25 (7), 1260-1272, 2016
1782016
A mechanistic view of enzyme evolution
G Yang, CM Miton, N Tokuriki
Protein Science 29 (8), 1724-1747, 2020
542020
Epistasis and intramolecular networks in protein evolution
CM Miton, K Buda, N Tokuriki
Current Opinion in Structural Biology 69 (August 2021), 160-168, 2021
472021
Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes
F Baier, N Hong, G Yang, A Pabis, CM Miton, A Barrozo, PD Carr, ...
Elife 8, e40789, 2019
422019
Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset
CM Miton, S Jonas, G Fischer, F Duarte, MF Mohamed, B van Loo, ...
Proceedings of the National Academy of Sciences 115 (31), E7293-E7302, 2018
322018
Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections
JN Copp, D Pletzer, AS Brown, J Van der Heijden, CM Miton, RJ Edgar, ...
MBio 11 (5), 10.1128/mbio. 02068-20, 2020
292020
Statistical analysis of mutational epistasis to reveal intramolecular interaction networks in proteins
CM Miton, JZ Chen, K Ost, DW Anderson, N Tokuriki
Methods in Enzymology 643, 243-280, 2020
212020
Insertions and deletions (indels): a missing piece of the protein engineering jigsaw
CM Miton, N Tokuriki
Biochemistry 62 (2), 148-157, 2022
132022
Molecular determinants of protein evolvability
K Buda, CM Miton, XC Fan, N Tokuriki
Trends in Biochemical Sciences, 2023
72023
Higher-order epistasis creates idiosyncrasy, confounding predictions in protein evolution
K Buda, CM Miton, N Tokuriki
bioRxiv, 2022.09. 07.505194, 2022
32022
Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
K Buda, CM Miton, N Tokuriki
Nature Communications 14 (1), 8508, 2023
12023
Leveraging ancestral sequence reconstruction for protein representation learning
DM Matthews, MA Spence, AC Mater, J Nichols, SB Pulsford, M Sandhu, ...
bioRxiv, 2023.12. 20.572683, 2023
12023
Origin Of Evolutionary Bifurcation In An Enzyme
CM Miton, EC Campbell, JA Kaczmarski, F Feixas, A Romero-Rivera, ...
bioRxiv, 2023.11. 25.568631, 2023
2023
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