| Functional amyloid–from bacteria to humans DM Fowler, AV Koulov, WE Balch, JW Kelly Trends in biochemical sciences 32 (5), 217-224, 2007 | 1202 | 2007 |
| Deep mutational scanning: a new style of protein science DM Fowler, S Fields Nature methods 11 (8), 801-807, 2014 | 1148 | 2014 |
| Functional amyloid formation within mammalian tissue DM Fowler, AV Koulov, C Alory-Jost, MS Marks, WE Balch, JW Kelly PLoS biology 4 (1), e6, 2006 | 1021 | 2006 |
| Semen-derived amyloid fibrils drastically enhance HIV infection J Münch, E Rücker, L Ständker, K Adermann, C Goffinet, M Schindler, ... Cell 131 (6), 1059-1071, 2007 | 650 | 2007 |
| High-resolution mapping of protein sequence-function relationships DM Fowler, CL Araya, SJ Fleishman, EH Kellogg, JJ Stephany, D Baker, ... Nature methods 7 (9), 741-746, 2010 | 616 | 2010 |
| Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization DA Bosco, DM Fowler, Q Zhang, J Nieva, ET Powers, P Wentworth, ... Nature chemical biology 2 (5), 249-253, 2006 | 414 | 2006 |
| Multiplex assessment of protein variant abundance by massively parallel sequencing KA Matreyek, LM Starita, JJ Stephany, B Martin, MA Chiasson, VE Gray, ... Nature genetics 50 (6), 874-882, 2018 | 408 | 2018 |
| Structure of the Sec13/31 COPII coat cage SM Stagg, C Gürkan, DM Fowler, P LaPointe, TR Foss, CS Potter, ... Nature 439 (7073), 234-238, 2006 | 392 | 2006 |
| Variant interpretation: functional assays to the rescue LM Starita, N Ahituv, MJ Dunham, JO Kitzman, FP Roth, G Seelig, ... The American Journal of Human Genetics 101 (3), 315-325, 2017 | 370 | 2017 |
| Massively parallel functional analysis of BRCA1 RING domain variants LM Starita, DL Young, M Islam, JO Kitzman, J Gullingsrud, RJ Hause, ... Genetics 200 (2), 413-422, 2015 | 341 | 2015 |
| A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function CL Araya, DM Fowler, W Chen, I Muniez, JW Kelly, S Fields Proceedings of the National Academy of Sciences 109 (42), 16858-16863, 2012 | 277 | 2012 |
| Deep mutational scanning: assessing protein function on a massive scale CL Araya, DM Fowler Trends in biotechnology 29 (9), 435-442, 2011 | 235 | 2011 |
| Pharmacogenomics of CYP2C9: Functional and Clinical Considerations† AK Daly, AE Rettie, DM Fowler, JO Miners Journal of personalized medicine 8 (1), 1, 2017 | 224 | 2017 |
| Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis LM Starita, JN Pruneda, RS Lo, DM Fowler, HJ Kim, JB Hiatt, J Shendure, ... Proceedings of the National Academy of Sciences 110 (14), E1263-E1272, 2013 | 222 | 2013 |
| The dynamin middle domain is critical for tetramerization and higher‐order self‐assembly R Ramachandran, M Surka, JS Chappie, DM Fowler, TR Foss, BD Song, ... The EMBO journal 26 (2), 559-566, 2007 | 214 | 2007 |
| Quantitative missense variant effect prediction using large-scale mutagenesis data VE Gray, RJ Hause, J Luebeck, J Shendure, DM Fowler Cell systems 6 (1), 116-124. e3, 2018 | 203 | 2018 |
| A statistical framework for analyzing deep mutational scanning data AF Rubin, H Gelman, N Lucas, SM Bajjalieh, AT Papenfuss, TP Speed, ... Genome biology 18, 1-15, 2017 | 201 | 2017 |
| MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect D Esposito, J Weile, J Shendure, LM Starita, AT Papenfuss, FP Roth, ... Genome biology 20, 1-11, 2019 | 195 | 2019 |
| Measuring the activity of protein variants on a large scale using deep mutational scanning DM Fowler, JJ Stephany, S Fields Nature protocols 9 (9), 2267-2284, 2014 | 188 | 2014 |
| A framework for exhaustively mapping functional missense variants J Weile, S Sun, AG Cote, J Knapp, M Verby, JC Mellor, Y Wu, C Pons, ... Molecular systems biology 13 (12), 957, 2017 | 185 | 2017 |
