david irwin
david irwin
Assistant professor, University Colorado Denver
Verified email at
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Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer
T Reid, F Valone, W Lipera, D Irwin, W Paroly, R Natale, S Sreedharan, ...
Lung cancer 45 (3), 381-386, 2004
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
MA Cavasin, K Demos-Davies, TR Horn, LA Walker, DD Lemon, ...
Circulation research 110 (5), 739-748, 2012
Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension
DD Lemon, TR Horn, MA Cavasin, MY Jeong, KW Haubold, CS Long, ...
Journal of molecular and cellular cardiology 51 (1), 41-50, 2011
Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress
DJ Reuland, S Khademi, CJ Castle, DC Irwin, JM McCord, BF Miller, ...
Free Radical Biology and Medicine 56, 102-111, 2013
A potential role for reactive oxygen species and the HIF-1α–VEGF pathway in hypoxia-induced pulmonary vascular leak
DC Irwin, JM McCord, E Nozik-Grayck, G Beckly, B Foreman, T Sullivan, ...
Free Radical Biology and Medicine 47 (1), 55-61, 2009
Neonatal lung side population cells demonstrate endothelial potential and are altered in response to hyperoxia-induced lung simplification
D Irwin, K Helm, N Campbell, M Imamura, K Fagan, J Harral, M Carr, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 293 (4 …, 2007
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma-and hypoxia-induced pulmonary hypertension
R Kumar, C Mickael, B Kassa, L Gebreab, JC Robinson, DE Koyanagi, ...
Nature communications 8 (1), 1-13, 2017
Nrf2 activation: a potential strategy for the prevention of acute mountain sickness
C Lisk, J McCord, S Bose, T Sullivan, Z Loomis, E Nozik-Grayck, ...
Free Radical Biology and Medicine 63, 264-273, 2013
Haptoglobin preserves vascular nitric oxide signaling during hemolysis
CA Schaer, JW Deuel, D Schildknecht, L Mahmoudi, I Garcia-Rubio, ...
American journal of respiratory and critical care medicine 193 (10), 1111-1122, 2016
Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers
DC Irwin, MC Tissot van Patot, A Tucker, R Bowen
American Journal of Physiology-Lung Cellular and Molecular Physiology 288 (5 …, 2005
Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension
JD West, ED Austin, C Gaskill, S Marriott, R Baskir, G Bilousova, JC Jean, ...
American Journal of Physiology-Cell Physiology 307 (5), C415-C430, 2014
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism
PW Buehler, JH Baek, C Lisk, I Connor, T Sullivan, D Kominsky, S Majka, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 303 (4 …, 2012
Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated …
DC Irwin, JH Baek, K Hassell, R Nuss, P Eigenberger, C Lisk, Z Loomis, ...
Free Radical Biology and Medicine 82, 50-62, 2015
Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension
B Wojciak-Stothard, VB Abdul-Salam, KH Lao, H Tsang, DC Irwin, C Lisk, ...
Circulation 129 (17), 1770-1780, 2014
Sympathetic inhibition attenuates hypoxia induced insulin resistance in healthy adult humans
GL Peltonen, RL Scalzo, MM Schweder, DG Larson, GJ Luckasen, D Irwin, ...
The Journal of Physiology 590 (11), 2801-2809, 2012
Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension
D Case, D Irwin, C Ivester, J Harral, K Morris, M Imamura, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 292 (1 …, 2007
Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension
E Nozik-Grayck, C Woods, JM Taylor, RKP Benninger, RD Johnson, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 307 …, 2014
Outdoor learning in Aotearoa New Zealand: Voices past, present, and future
M Cosgriff, M Legge, M Brown, M Boyes, R Zink, D Irwin
Journal of Adventure Education & Outdoor Learning 12 (3), 221-235, 2012
The splenic syndrome in individuals with sickle cell trait
J Goodman, K Hassell, D Irwin, EH Witkowski, R Nuss
High altitude medicine & biology 15 (4), 468-471, 2014
Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats
BJ Engebretsen, D Irwin, ME Valdez, MK O'Donovan, A Tucker, ...
High Altitude Medicine & Biology 8 (4), 312-321, 2007
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