Arvind Rajpal
Arvind Rajpal
Senior Vice President, Xaira
Verified email at - Homepage
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Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
J Glanville, W Zhai, J Berka, D Telman, G Huerta, GR Mehta, I Ni, L Mei, ...
Proceedings of the National Academy of Sciences 106 (48), 20216-20221, 2009
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates
P Strop, SH Liu, M Dorywalska, K Delaria, RG Dushin, TT Tran, WH Ho, ...
Chemistry & biology 20 (2), 161-167, 2013
Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements
KJL Jackson, Y Liu, KM Roskin, J Glanville, RA Hoh, K Seo, EL Marshall, ...
Cell host & microbe 16 (1), 105-114, 2014
VISTA is an acidic pH-selective ligand for PSGL-1
RJ Johnston, LJ Su, J Pinckney, D Critton, E Boyer, A Krishnakumar, ...
Nature 574 (7779), 565-570, 2019
A general method for greatly improving the affinity of antibodies by using combinatorial libraries
A Rajpal, N Beyaz, L Haber, G Cappuccilli, H Yee, RR Bhatt, T Takeuchi, ...
Proceedings of the National Academy of Sciences 102 (24), 8466-8471, 2005
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
J Glanville, TC Kuo, HC von Büdingen, L Guey, J Berka, PD Sundar, ...
Proceedings of the National Academy of Sciences 108 (50), 20066-20071, 2011
Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair
P Strop, WH Ho, LM Boustany, YN Abdiche, KC Lindquist, SE Farias, ...
Journal of molecular biology 420 (3), 204-219, 2012
Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9
J Chaparro-Riggers, H Liang, RM DeVay, L Bai, JE Sutton, W Chen, ...
Journal of Biological Chemistry 287 (14), 11090-11097, 2012
Molecular basis of valine-citrulline-PABC linker instability in site-specific ADCs and its mitigation by linker design
M Dorywalska, R Dushin, L Moine, SE Farias, D Zhou, T Navaratnam, ...
Molecular cancer therapeutics 15 (5), 958-970, 2016
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity
YN Abdiche, YA Yeung, J Chaparro-Riggers, I Barman, P Strop, SM Chin, ...
MAbs 7 (2), 331-343, 2015
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
A Rajpal, YA Cho, B Yelent, PH Koza‐Taylor, D Li, E Chen, M Whang, ...
The EMBO journal, 2003
Effect of attachment site on stability of cleavable antibody drug conjugates
M Dorywalska, P Strop, JA Melton-Witt, A Hasa-Moreno, SE Farias, ...
Bioconjugate chemistry 26 (4), 650-659, 2015
Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
LF Lee, K Logronio, GH Tu, W Zhai, I Ni, L Mei, J Dilley, J Yu, A Rajpal, ...
Proceedings of the National Academy of Sciences 109 (31), 12674-12679, 2012
Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading
P Strop, K Delaria, D Foletti, JM Witt, A Hasa-Moreno, K Poulsen, ...
Nature biotechnology 33 (7), 694-696, 2015
Energetic analysis of an antigen/antibody interface: alanine scanning mutagenesis and double mutant cycles on the HyHEL-10/lysozyme interaction
J Pons, A Rajpal, JF Kirsch
Protein science 8 (5), 958-968, 1999
Anti-PCSK9 antibodies with pH dependent antigen binding
J Pons, JR Chabot, JFC Riggers, BC Gomes, H Liang, K Mayawala, ...
US Patent 9,029,515, 2015
Heterodimeric proteins and methods for producing and purifying them
WH Ho, J Pons, A Rajpal, P Strop
US Patent 9,527,926, 2016
High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region
MJ Osborn, B Ma, S Avis, A Binnie, J Dilley, X Yang, K Lindquist, ...
The Journal of Immunology 190 (4), 1481-1490, 2013
Preclinical evaluation of allogeneic CAR T cells targeting BCMA for the treatment of multiple myeloma
C Sommer, B Boldajipour, TC Kuo, T Bentley, J Sutton, A Chen, T Geng, ...
Molecular therapy 27 (6), 1126-1138, 2019
Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates
H Liang, J Chaparro-Riggers, P Strop, T Geng, JE Sutton, D Tsai, L Bai, ...
Journal of Pharmacology and Experimental Therapeutics 340 (2), 228-236, 2012
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