| mTOR signaling in growth, metabolism, and disease RA Saxton, DM Sabatini Cell 168 (6), 960-976, 2017 | 5808 | 2017 |
| Sestrin2 is a leucine sensor for the mTORC1 pathway RL Wolfson, L Chantranupong, RA Saxton, K Shen, SM Scaria, JR Cantor, ... Science 351 (6268), 43-48, 2016 | 970 | 2016 |
| The CASTOR proteins are arginine sensors for the mTORC1 pathway L Chantranupong, SM Scaria, RA Saxton, MP Gygi, K Shen, GA Wyant, ... Cell 165 (1), 153-164, 2016 | 622 | 2016 |
| The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 L Chantranupong, RL Wolfson, JM Orozco, RA Saxton, SM Scaria, ... Cell reports 9 (1), 1-8, 2014 | 407 | 2014 |
| Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway RA Saxton, KE Knockenhauer, RL Wolfson, L Chantranupong, ME Pacold, ... Science 351 (6268), 53-58, 2016 | 382 | 2016 |
| SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway X Gu, JM Orozco, RA Saxton, KJ Condon, GY Liu, PA Krawczyk, ... Science 358 (6364), 813-818, 2017 | 379 | 2017 |
| Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 RA Saxton, L Chantranupong, KE Knockenhauer, TU Schwartz, ... Nature 536 (7615), 229-233, 2016 | 252 | 2016 |
| Topological control of cytokine receptor signaling induces differential effects in hematopoiesis K Mohan, G Ueda, AR Kim, KM Jude, JA Fallas, Y Guo, M Hafer, Y Miao, ... Science 364 (6442), eaav7532, 2019 | 65 | 2019 |
| Dimerization quality control ensures neuronal development and survival EL Mena, RAS Kjolby, RA Saxton, A Werner, BG Lew, JM Boyle, ... Science 362 (6411), eaap8236, 2018 | 53 | 2018 |
| Structure-based decoupling of the pro-and anti-inflammatory functions of interleukin-10 RA Saxton, N Tsutsumi, LL Su, GC Abhiraman, K Mohan, LT Henneberg, ... Science 371 (6535), eabc8433, 2021 | 49 | 2021 |
| Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation CR Glassman, N Tsutsumi, RA Saxton, PJ Lupardus, KM Jude, KC Garcia Science 376 (6589), 163-169, 2022 | 33 | 2022 |
| The apo-structure of the leucine sensor Sestrin2 is still elusive RA Saxton, KE Knockenhauer, TU Schwartz, DM Sabatini Science signaling 9 (446), ra92-ra92, 2016 | 25 | 2016 |
| The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design RA Saxton, LT Henneberg, M Calafiore, L Su, KM Jude, AM Hanash, ... Immunity 54 (4), 660-672. e9, 2021 | 23 | 2021 |
| Structure of the nutrient-sensing hub GATOR2 ML Valenstein, KB Rogala, PV Lalgudi, EJ Brignole, X Gu, RA Saxton, ... Nature 607 (7919), 610-616, 2022 | 15 | 2022 |
| METHODS OF IDENTIFYING MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USE OF SAME TO MODULATE mTORC1 DM Sabatini, L Chantranupong, RL Wolfson, J Orozco, RA Saxton, ... | 3 | 2016 |
| Emerging principles of cytokine pharmacology and therapeutics RA Saxton, CR Glassman, KC Garcia Nature Reviews Drug Discovery 22 (1), 21-37, 2023 | 2 | 2023 |
| Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineering RA Saxton, KC Garcia The FEBS journal 289 (24), 8032-8036, 2022 | 1 | 2022 |
| Structural basis of Janus kinase trans-activation NA Caveney, RA Saxton, D Waghray, CR Glassman, N Tsutsumi, ... Cell Reports 42 (3), 2023 | | 2023 |
| Methods of identifying modulators of CASTOR1-GATOR2 interaction and use of same to modulate mTORC1 DM Sabatini, L Chantranupong, RA Saxton, SP Gygi, MP Gygi US Patent 11,092,608, 2021 | | 2021 |
| Mechanisms of amino acid sensing by the mTORC1 pathway RA Saxton Massachusetts Institute of Technology, 2018 | | 2018 |
David M. SabatiniWhitehead Institute/MIT/HHMIПодтвержден адрес электронной почты в домене wi.mit.edu
