| GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling ARB Thomsen, B Plouffe, TJ Cahill, AK Shukla, JT Tarrasch, AM Dosey, ... Cell 166 (4), 907-919, 2016 | 534 | 2016 |
| Visualization of arrestin recruitment by a G-protein-coupled receptor AK Shukla, GH Westfield, K Xiao, RI Reis, LY Huang, P Tripathi-Shukla, ... Nature 512 (7513), 218-222, 2014 | 518 | 2014 |
| Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide AK Shukla, A Manglik, AC Kruse, K Xiao, RI Reis, WC Tseng, DP Staus, ... Nature 497 (7447), 137-141, 2013 | 461 | 2013 |
| Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis TJ Cahill III, ARB Thomsen, JT Tarrasch, B Plouffe, AH Nguyen, F Yang, ... Proceedings of the National Academy of Sciences 114 (10), 2562-2567, 2017 | 363 | 2017 |
| Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex AH Nguyen, ARB Thomsen, TJ Cahill III, R Huang, LY Huang, T Marcink, ... Nature structural & molecular biology 26 (12), 1123-1131, 2019 | 163 | 2019 |
| Identification of medically important molds by an oligonucleotide array CR Hsiao, L Huang, JP Bouchara, R Barton, HC Li, TC Chang Journal of clinical microbiology 43 (8), 3760-3768, 2005 | 156 | 2005 |
| Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model JM Becker, SJ Kauffman, M Hauser, L Huang, M Lin, S Sillaots, B Jiang, ... Proceedings of the National Academy of Sciences 107 (51), 22044-22049, 2010 | 148 | 2010 |
| Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus R Rodriguez-Suarez, D Xu, K Veillette, J Davison, S Sillaots, S Kauffman, ... Chemistry & biology 14 (10), 1163-1175, 2007 | 98 | 2007 |
| Mechanism of β2AR regulation by an intracellular positive allosteric modulator X Liu, A Masoudi, AW Kahsai, LY Huang, B Pani, DP Staus, PJ Shim, ... Science 364 (6447), 1283-1287, 2019 | 88 | 2019 |
| Small-molecule positive allosteric modulators of the β2-adrenoceptor isolated from DNA-encoded libraries S Ahn, B Pani, AW Kahsai, EK Olsen, G Husemoen, M Vestergaard, L Jin, ... Molecular pharmacology 94 (2), 850-861, 2018 | 72 | 2018 |
| Unnatural amino acid replacement in a yeast G protein-coupled receptor in its native environment LY Huang, G Umanah, M Hauser, C Son, B Arshava, F Naider, JM Becker Biochemistry 47 (20), 5638-5648, 2008 | 53 | 2008 |
| GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision WB Asher, DS Terry, GGA Gregorio, AW Kahsai, A Borgia, B Xie, A Modak, ... Cell 185 (10), 1661-1675. e16, 2022 | 48 | 2022 |
| Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass … GKE Umanah, L Huang, F Ding, B Arshava, AR Farley, AJ Link, F Naider, ... Journal of biological chemistry 285 (50), 39425-39436, 2010 | 34 | 2010 |
| Changes in conformation at the cytoplasmic ends of the fifth and sixth transmembrane helices of a yeast G protein-coupled receptor in response to ligand binding GKE Umanah, LY Huang, JM Maccarone, F Naider, JM Becker Biochemistry 50 (32), 6841-6854, 2011 | 32 | 2011 |
| The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus Y Zang, AW Kahsai, N Pakharukova, L Huang, RJ Lefkowitz Journal of Biological Chemistry 297 (6), 2021 | 10 | 2021 |
| Incorporation of the Unnatural Amino Acid p-benzoyl-L-phenylalanine (Bpa) into a G Protein-coupled Receptor in its Native Context G Umanah, LY Huang, PG Schultz, F Naider, JM Becker Peptides for Youth: The Proceedings of the 20th American Peptide Symposium …, 2009 | 8 | 2009 |
| β-arrestin2 mediates progression of murine primary myelofibrosis LRJ 4. Rein LAM, Wisler JW, Kim J, Theriot B, Huang LY, Price T, Yang H ... JCI Insight 2 (24), e98094, 2017 | 5 | 2017 |
| Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin AW Kahsai, KS Shah, PJ Shim, MA Lee, BN Shreiber, AM Schwalb, ... Proceedings of the National Academy of Sciences 120 (43), e2303794120, 2023 | 2 | 2023 |
| β-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis LAM Rein, JW Wisler, BS Theriot, LY Huang, RT Premont, RJ Lefkowitz Blood 126 (23), 486, 2015 | | 2015 |
| Interaction of a G protein-coupled receptor (Ste2p) of Saccharomyces cerevisiae with its ligand and its G-protein alpha subunit LY Huang | | 2011 |
