| A three-dimensional human neural cell culture model of Alzheimer’s disease SH Choi, YH Kim, M Hebisch, C Sliwinski, S Lee, C D’Avanzo, H Chen, ... Nature 515 (7526), 274-278, 2014 | 1271 | 2014 |
| Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs J Hanna, AW Cheng, K Saha, J Kim, CJ Lengner, F Soldner, JP Cassady, ... Proceedings of the National Academy of Sciences 107 (20), 9222-9227, 2010 | 1012 | 2010 |
| Efficient derivation of microglia-like cells from human pluripotent stem cells J Muffat, Y Li, B Yuan, M Mitalipova, A Omer, S Corcoran, G Bakiasi, ... Nature medicine 22 (11), 1358-1367, 2016 | 597 | 2016 |
| Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease LE Goldstein, JA Muffat, RA Cherny, RD Moir, MH Ericsson, X Huang, ... The Lancet 361 (9365), 1258-1265, 2003 | 585 | 2003 |
| Identification and rescue of α-synuclein toxicity in Parkinson patient–derived neurons CY Chung, V Khurana, PK Auluck, DF Tardiff, JR Mazzulli, F Soldner, ... Science 342 (6161), 983-987, 2013 | 512 | 2013 |
| Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations CJ Lengner, AA Gimelbrant, JA Erwin, AW Cheng, MG Guenther, ... Cell 141 (5), 872-883, 2010 | 459 | 2010 |
| Rescue of fragile X syndrome neurons by DNA methylation editing of the FMR1 gene XS Liu, H Wu, M Krzisch, X Wu, J Graef, J Muffat, D Hnisz, CH Li, B Yuan, ... Cell 172 (5), 979-992. e6, 2018 | 441 | 2018 |
| Induction of expansion and folding in human cerebral organoids Y Li, J Muffat, A Omer, I Bosch, MA Lancaster, M Sur, L Gehrke, ... Cell stem cell 20 (3), 385-396. e3, 2017 | 394 | 2017 |
| Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons Y Li, H Wang, J Muffat, AW Cheng, DA Orlando, J Lovén, S Kwok, ... Cell stem cell 13 (4), 446-458, 2013 | 343 | 2013 |
| 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote α-crystallin cross-linking by metal ion reduction LE Goldstein, MC Leopold, X Huang, CS Atwood, AJ Saunders, ... Biochemistry 39 (24), 7266-7275, 2000 | 241 | 2000 |
| Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions K Saha, Y Mei, CM Reisterer, NK Pyzocha, J Yang, J Muffat, MC Davies, ... Proceedings of the National Academy of Sciences 108 (46), 18714-18719, 2011 | 176 | 2011 |
| ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state Y Chudnovsky, D Kim, S Zheng, WA Whyte, M Bansal, MA Bray, S Gopal, ... Cell reports 6 (2), 313-324, 2014 | 163 | 2014 |
| Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz J Hull-Thompson, J Muffat, D Sanchez, DW Walker, S Benzer, ... PLoS genetics 5 (4), e1000460, 2009 | 155 | 2009 |
| Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan DW Walker, J Muffat, C Rundel, S Benzer Current Biology 16 (7), 674-679, 2006 | 150 | 2006 |
| Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila J Muffat, DW Walker, S Benzer Proceedings of the National Academy of Sciences 105 (19), 7088-7093, 2008 | 132 | 2008 |
| Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant DW Walker, P Hájek, J Muffat, D Knoepfle, S Cornelison, G Attardi, ... Proceedings of the National Academy of Sciences 103 (44), 16382-16387, 2006 | 118 | 2006 |
| Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections J Muffat, Y Li, A Omer, A Durbin, I Bosch, G Bakiasi, E Richards, A Meyer, ... Proceedings of the National Academy of Sciences 115 (27), 7117-7122, 2018 | 116 | 2018 |
| Genome-wide CRISPR screen for Zika virus resistance in human neural cells Y Li, J Muffat, A Omer Javed, HR Keys, T Lungjangwa, I Bosch, M Khan, ... Proceedings of the National Academy of Sciences 116 (19), 9527-9532, 2019 | 99 | 2019 |
| Apolipoprotein D: an overview of its role in aging and age-related diseases J Muffat, DW Walker Cell Cycle 9 (2), 269-273, 2010 | 79 | 2010 |
| Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases M Trapecar, E Wogram, D Svoboda, C Communal, A Omer, ... Science Advances 7 (5), eabd1707, 2021 | 78 | 2021 |
Yun LiPrincipal Investigator, the Hospital for Sick Children. Assistant Professor, University of TorontoVerified email at sickkids.ca
