| Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene A Poltorak, X He, I Smirnova, MY Liu, CV Huffel, X Du, D Birdwell, ... Science 282 (5396), 2085-2088, 1998 | 10162 | 1998 |
| Three novel mammalian toll-like receptors: gene structure, expression, and evolution. X Du, A Poltorak, Y Wei, B Beutler European cytokine network 11 (3), 362-71, 2000 | 695 | 2000 |
| Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection J Sarhan, BC Liu, HI Muendlein, P Li, R Nilson, AY Tang, A Rongvaux, ... Proceedings of the National Academy of Sciences 115 (46), E10888-E10897, 2018 | 643 | 2018 |
| Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation A Poltorak, P Ricciardi-Castagnoli, S Citterio, B Beutler Proceedings of the National Academy of Sciences 97 (5), 2163-2167, 2000 | 566 | 2000 |
| Genetic and physical mapping of theLpsLocus: identification of the Toll-4 receptor as a candidate gene in the critical region A Poltorak, I Smirnova, X He, MY Liu, C Van Huffel, D Birdwell, E Alejos, ... Blood Cells, Molecules, and Diseases 24 (3), 340-355, 1998 | 543 | 1998 |
| PU. 1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene M Rehli, A Poltorak, L Schwarzfischer, SW Krause, R Andreesen, ... Journal of Biological Chemistry 275 (13), 9773-9781, 2000 | 289 | 2000 |
| RIPK1 and RIPK3 kinases promote cell-death-independent inflammation by toll-like receptor 4 M Najjar, D Saleh, M Zelic, S Nogusa, S Shah, A Tai, JN Finger, ... Immunity 45 (1), 46-59, 2016 | 276 | 2016 |
| Cutting edge: activation of STING in T cells induces type I IFN responses and cell death B Larkin, V Ilyukha, M Sorokin, A Buzdin, E Vannier, A Poltorak The Journal of Immunology 199 (2), 397-402, 2017 | 271 | 2017 |
| Sepsis and evolution of the innate immune response B Beutler, A Poltorak Critical care medicine 29 (7), S2-S6, 2001 | 256 | 2001 |
| Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4) I Smirnova, A Poltorak, EKL Chan, C McBride, B Beutler Genome biology 1, 1-10, 2000 | 207 | 2000 |
| Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies B Beutler, X Du, A Poltorak Journal of endotoxin research 7 (4), 277-280, 2001 | 198 | 2001 |
| Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis J Sarhan, BC Liu, HI Muendlein, CG Weindel, I Smirnova, AY Tang, ... Cell Death & Differentiation 26 (2), 332-347, 2019 | 157 | 2019 |
| Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor X Du, A Poltorak, M Silva, B Beutler Blood Cells, Molecules, and Diseases 25 (6), 328-338, 1999 | 151 | 1999 |
| Toll‐like receptor 4 expression levels determine the degree of LPS‐susceptibility in mice C Kalis, B Kanzler, A Lembo, A Poltorak, C Galanos, MA Freudenberg European journal of immunology 33 (3), 798-805, 2003 | 141 | 2003 |
| The role of toll‐like receptor 4 versus interleukin‐12 in immunity to respiratory syncytial virus S Ehl, R Bischoff, T Ostler, S Vallbracht, J Schulte‐Mönting, A Poltorak, ... European journal of immunology 34 (4), 1146-1153, 2004 | 138 | 2004 |
| Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family. M Mohamadzadeh, AN Poltorak, PR Bergstressor, B Beutler, ... Journal of immunology (Baltimore, Md.: 1950) 156 (9), 3102-3106, 1996 | 125 | 1996 |
| Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice A Poltorak, I Smirnova, R Clisch, B Beutler Journal of Endotoxin Research 6 (1), 51-56, 2000 | 117 | 2000 |
| cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation HI Muendlein, D Jetton, WM Connolly, KP Eidell, Z Magri, I Smirnova, ... Science 367 (6484), 1379-1384, 2020 | 94 | 2020 |
| Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response. B Beutler, A Poltorak European cytokine network 11 (2), 143-52, 2000 | 90 | 2000 |
| A point mutation in the IL-12Rβ2 gene underlies the IL-12 unresponsiveness of LPS-defective C57BL/10ScCr mice A Poltorak, T Merlin, PJ Nielsen, O Sandra, I Smirnova, I Schupp, ... The Journal of Immunology 167 (4), 2106-2111, 2001 | 87 | 2001 |
