Inhibitory effects of cannabidiol on voltage-dependent sodium currents MR Ghovanloo, NG Shuart, J Mezeyova, RA Dean, PC Ruben, ... Journal of Biological Chemistry 293 (43), 16546-16558, 2018 | 171 | 2018 |
Allosteric block of KCa2 channels by apamin C Lamy, SJ Goodchild, KL Weatherall, DE Jane, JF Liégeois, V Seutin, ... Journal of Biological Chemistry 285 (35), 27067-27077, 2010 | 110 | 2010 |
Small conductance calcium-activated potassium channels: from structure to function KL Weatherall, SJ Goodchild, DE Jane, NV Marrion Progress in neurobiology 91 (3), 242-255, 2010 | 99 | 2010 |
Local anesthetic inhibition of a bacterial sodium channel S Lee, SJ Goodchild, CA Ahern Journal of General Physiology 139 (6), 507-516, 2012 | 70 | 2012 |
Selective NaV1. 7 antagonists with long residence time show improved efficacy against inflammatory and neuropathic pain G Bankar, SJ Goodchild, S Howard, K Nelkenbrecher, M Waldbrook, ... Cell reports 24 (12), 3133-3145, 2018 | 53 | 2018 |
Cannabidiol inhibits the skeletal muscle Nav1. 4 by blocking its pore and by altering membrane elasticity MR Ghovanloo, K Choudhury, TS Bandaru, MA Fouda, K Rayani, ... Journal of General Physiology 153 (5), e202012701, 2021 | 45 | 2021 |
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa … T Focken, S Chowdhury, A Zenova, ME Grimwood, C Chabot, T Sheng, ... Journal of medicinal chemistry 61 (11), 4810-4831, 2018 | 31 | 2018 |
NBI-921352, a first-in-class, NaV1. 6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats JP Johnson, T Focken, K Khakh, PK Tari, C Dube, SJ Goodchild, ... Elife 11, e72468, 2022 | 28 | 2022 |
Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways SJ Goodchild, LC Macdonald, D Fedida Biophysical journal 108 (6), 1435-1447, 2015 | 28 | 2015 |
Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels Z Wang, Y Dou, SJ Goodchild, Z Es-Salah-Lamoureux, D Fedida Journal of General Physiology 141 (4), 431-443, 2013 | 28 | 2013 |
Tris-pyrazolylborate complexes of redox inactive lanthanides–the structures of [(TpMe2) 2NdX](X= Cl, NPh2, dpm, H2BEt2) JL Galler, S Goodchild, J Gould, R McDonald, A Sella Polyhedron 23 (2-3), 253-262, 2004 | 24 | 2004 |
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy T Focken, K Burford, ME Grimwood, A Zenova, JC Andrez, W Gong, ... Journal of medicinal chemistry 62 (21), 9618-9641, 2019 | 22 | 2019 |
Gating charge movement precedes ionic current activation in hERG channels SJ Goodchild, D Fedida Channels 8 (1), 84-89, 2014 | 22 | 2014 |
Inhibition of KCa2.2 and KCa2.3 channel currents by protonation of outer pore histidine residues SJ Goodchild, C Lamy, V Seutin, NV Marrion Journal of General Physiology 134 (4), 295-308, 2009 | 18 | 2009 |
Molecular and functional determinants of local anesthetic inhibition of NaChBac S Lee, SJ Goodchild, CA Ahern Channels 6 (5), 403-406, 2012 | 17 | 2012 |
Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations SJ Goodchild, H Xu, Z Es-Salah-Lamoureux, CA Ahern, D Fedida Journal of General Physiology 140 (5), 495-511, 2012 | 16 | 2012 |
Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant Z Es-Salah-Lamoureux, PY Xiong, SJ Goodchild, CA Ahern, D Fedida Biophysical journal 101 (3), 662-670, 2011 | 13 | 2011 |
Contributions of intracellular ions to Kv channel voltage sensor dynamics SJ Goodchild, D Fedida Frontiers in Pharmacology 3, 114, 2012 | 9 | 2012 |
The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium Y Dou, SJ Goodchild, RV Velde, Y Wu, D Fedida American Journal of Physiology-Cell Physiology 305 (4), C468-C478, 2013 | 8 | 2013 |
Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study MR Ghovanloo, SJ Goodchild, PC Ruben Plos one 17 (8), e0271801, 2022 | 7 | 2022 |