Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis T Hayami, M Pickarski, Y Zhuo, GA Wesolowski, GA Rodan, LT Duong Bone 38 (2), 234-243, 2006 | 783 | 2006 |
The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior … T Hayami, M Pickarski, GA Wesolowski, J Mclane, A Bone, J Destefano, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2004 | 724 | 2004 |
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K JY Gauthier, N Chauret, W Cromlish, S Desmarais, LT Duong, ... Bioorganic & medicinal chemistry letters 18 (3), 923-928, 2008 | 536 | 2008 |
Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells E Jimi, I Nakamura, LT Duong, T Ikebe, N Takahashi, GA Rodan, T Suda Experimental cell research 247 (1), 84-93, 1999 | 457 | 1999 |
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha (v) beta3 integrin, and phosphorylated by src kinase. LT Duong, PT Lakkakorpi, I Nakamura, M Machwate, RM Nagy, ... The Journal of clinical investigation 102 (5), 881-892, 1998 | 296 | 1998 |
Integrins and signaling in osteoclast function LT Duong, P Lakkakorpi, I Nakamura, GA Rodan Matrix Biology 19 (2), 97-105, 2000 | 295 | 2000 |
Role of αvβ3 integrin in osteoclast migration and formation of the sealing zone I Nakamura, MF Pilkington, PT Lakkakorpi, L Lipfert, SM Sims, SJ Dixon, ... Journal of cell science 112 (22), 3985-3993, 1999 | 256 | 1999 |
Involvement of αvβ3 integrins in osteoclast function I Nakamura, LT Duong, SB Rodan, GA Rodan Journal of bone and mineral metabolism 25, 337-344, 2007 | 250 | 2007 |
The osteoclast, bone remodelling and treatment of metabolic bone disease BF Boyce, E Rosenberg, AE de Papp, LT Duong European journal of clinical investigation 42 (12), 1332-1341, 2012 | 240 | 2012 |
Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator SJ Gardell, LT Duong, RE Diehl, JD York, TR Hare, RB Register, ... Journal of Biological Chemistry 264 (30), 17947-17952, 1989 | 219 | 1989 |
Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double‐blind, randomized, placebo‐controlled phase I studies SA Stoch, S Zajic, J Stone, DL Miller, K Van Dyck, MJ Gutierrez, ... Clinical Pharmacology & Therapeutics 86 (2), 175-182, 2009 | 197 | 2009 |
Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. T Hayami, H Funaki, K Yaoeda, K Mitui, H Yamagiwa, K Tokunaga, ... The Journal of rheumatology 30 (10), 2207-2217, 2003 | 166 | 2003 |
Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized … T Cusick, CM Chen, BL Pennypacker, M Pickarski, DB Kimmel, BB Scott, ... Journal of Bone and Mineral Research 27 (3), 524-537, 2012 | 151 | 2012 |
Stable association of PYK2 and p130Cas in osteoclasts and their co-localization in the sealing zone PT Lakkakorpi, I Nakamura, RM Nagy, JT Parsons, GA Rodan, LT Duong Journal of Biological Chemistry 274 (8), 4900-4907, 1999 | 138 | 1999 |
The αvβ3 integrin regulates α5β1-mediated cell migration toward fibronectin KO Simon, EM Nutt, DG Abraham, GA Rodan, LT Duong Journal of Biological Chemistry 272 (46), 29380-29389, 1997 | 138 | 1997 |
Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts I Nakamura, E Jimi, LT Duong, T Sasaki, N Takahashi, GA Rodan, T Suda Journal of Biological Chemistry 273 (18), 11144-11149, 1998 | 137 | 1998 |
Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis T Hayami, YA Zhuo, GA Wesolowski, M Pickarski, LT Duong Bone 50 (6), 1250-1259, 2012 | 136 | 2012 |
PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption PT Lakkakorpi, AJ Bett, L Lipfert, GA Rodan, T Duong Journal of Biological Chemistry 278 (13), 11502-11512, 2003 | 130 | 2003 |
Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys PJ Masarachia, BL Pennypacker, M Pickarski, KR Scott, GA Wesolowski, ... Journal of Bone and Mineral Research 27 (3), 509-523, 2012 | 125 | 2012 |
Nonpeptide αvβ3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent αvβ3 Antagonists for the Prevention and Treatment of Osteoporosis PJ Coleman, KM Brashear, BC Askew, JH Hutchinson, CA McVean, ... Journal of medicinal chemistry 47 (20), 4829-4837, 2004 | 124 | 2004 |