Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor RB Laprairie, AM Bagher, MEM Kelly, EM Denovan‐Wright British journal of pharmacology 172 (20), 4790-4805, 2015 | 1038 | 2015 |
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice E Rodriguez-Lebron, EM Denovan-Wright, K Nash, AS Lewin, RJ Mandel Molecular therapy 12 (4), 618-633, 2005 | 327 | 2005 |
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors M Tham, O Yilmaz, M Alaverdashvili, MEM Kelly, EM Denovan‐Wright, ... British journal of pharmacology 176 (10), 1455-1469, 2019 | 275 | 2019 |
Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington′ s disease transgenic mice prior to the onset of motor symptoms ALO Hebb, HA Robertson, EM Denovan-Wright Neuroscience 123 (4), 967-981, 2004 | 201 | 2004 |
Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington’s disease mice EM Denovan-Wright, HA Robertson Neuroscience 98 (4), 705-713, 2000 | 193 | 2000 |
Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons RB Laprairie, AM Bagher, MEM Kelly, DJ Dupré, EM Denovan-Wright Journal of Biological Chemistry 289 (36), 24845-24862, 2014 | 154 | 2014 |
Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice EA McCaw, H Hu, GT Gomez, ALO Hebb, MEM Kelly, ... European journal of biochemistry 271 (23‐24), 4909-4920, 2004 | 135 | 2004 |
Gene–environment interplay in the etiology of psychosis A Zwicker, EM Denovan-Wright, R Uher Psychological medicine 48 (12), 1925-1936, 2018 | 126 | 2018 |
Complete sequence of the mitochondrial DNA of Chlamydomonas eugametos EM Denovan-Wright, AM Nedelcu, RW Lee Plant molecular biology 36, 285-295, 1998 | 101 | 1998 |
Anti‐inflammatory effects of cannabinoid CB2 receptor activation in endotoxin‐induced uveitis JT Toguri, C Lehmann, RB Laprairie, AM Szczesniak, J Zhou, ... British journal of pharmacology 171 (6), 1448-1461, 2014 | 99 | 2014 |
Enantiospecific allosteric modulation of cannabinoid 1 receptor RB Laprairie, PM Kulkarni, JR Deschamps, MEM Kelly, DR Janero, ... ACS chemical neuroscience 8 (6), 1188-1203, 2017 | 98 | 2017 |
Biased type 1 cannabinoid receptor signaling influences neuronal viability in a cell culture model of Huntington disease RB Laprairie, AM Bagher, MEM Kelly, EM Denovan-Wright Molecular Pharmacology 89 (3), 364-375, 2016 | 98 | 2016 |
Mutant huntingtin affects the rate of transcription of striatum‐specific isoforms of phosphodiesterase 10A H Hu, EA McCaw, ALO Hebb, GT Gomez, EM Denovan‐Wright European Journal of Neuroscience 20 (12), 3351-3363, 2004 | 93 | 2004 |
T-type calcium channel α1G and α1H subunits in human retinoblastoma cells and their loss after differentiation K Hirooka, GE Bertolesi, MEM Kelly, EM Denovan-Wright, X Sun, J Hamid, ... Journal of neurophysiology 88 (1), 196-205, 2002 | 85 | 2002 |
The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription RB Laprairie, MEM Kelly, EM Denovan‐Wright British journal of pharmacology 167 (8), 1583-1595, 2012 | 79 | 2012 |
Cannabinoid receptor ligand bias: implications in the central nervous system RB Laprairie, AM Bagher, EM Denovan-Wright Current opinion in pharmacology 32, 32-43, 2017 | 77 | 2017 |
Structure, linkage mapping and expression of the heart‐type fatty acid‐binding protein gene (fabp3 ) from zebrafish (Danio rerio) RZ Liu, EM Denovan‐Wright, JM Wright European journal of biochemistry 270 (15), 3223-3234, 2003 | 76 | 2003 |
Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue‐specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome MK Sharma, RZ Liu, C Thisse, B Thisse, EM Denovan‐Wright, JM Wright The FEBS journal 273 (14), 3216-3229, 2006 | 72 | 2006 |
cDNA sequence and tissue-specific expression of a basic liver-type fatty acid binding protein in adult zebrafish (Danio rerio) EM Denovan-Wright, M Pierce, MK Sharma, JM Wright Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1492 (1 …, 2000 | 69 | 2000 |
Novel electrophilic and photoaffinity covalent probes for mapping the cannabinoid 1 receptor allosteric site (s) PM Kulkarni, AR Kulkarni, A Korde, RB Tichkule, RB Laprairie, ... Journal of medicinal chemistry 59 (1), 44-60, 2016 | 65 | 2016 |