Mutation effects predicted from sequence co-variation TA Hopf, JB Ingraham, FJ Poelwijk, CPI Schärfe, M Springer, C Sander, ... Nature biotechnology 35 (2), 128-135, 2017 | 656 | 2017 |
Sequence co-evolution gives 3D contacts and structures of protein complexes TA Hopf, CPI Schärfe, JP Rodrigues, AG Green, O Kohlbacher, C Sander, ... elife 3, e03430, 2014 | 535 | 2014 |
The EVcouplings Python framework for coevolutionary sequence analysis TA Hopf, AG Green, B Schubert, S Mersmann, CPI Schärfe, JB Ingraham, ... Bioinformatics 35 (9), 1582-1584, 2019 | 231 | 2019 |
Genetic variation in human drug-related genes CPI Schärfe, R Tremmel, M Schwab, O Kohlbacher, DS Marks Genome medicine 9, 1-15, 2017 | 133 | 2017 |
The MoSGrid science gateway–a complete solution for molecular simulations J Krüger, R Grunzke, S Gesing, S Breuers, A Brinkmann, L de la Garza, ... Journal of Chemical Theory and Computation 10 (6), 2232-2245, 2014 | 87 | 2014 |
Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization M Avbelj, OO Wolz, O Fekonja, M Benčina, M Repič, J Mavri, J Krüger, ... Blood, The Journal of the American Society of Hematology 124 (26), 3896-3904, 2014 | 86 | 2014 |
Structural and functional characterization of the bacterial type III secretion export apparatus T Dietsche, M Tesfazgi Mebrhatu, MJ Brunner, P Abrusci, J Yan, ... PLoS pathogens 12 (12), e1006071, 2016 | 84 | 2016 |
Structure and sequence analyses of clustered protocadherins reveal antiparallel interactions that mediate homophilic specificity JM Nicoludis, SY Lau, CPI Schärfe, DS Marks, WA Weihofen, R Gaudet Structure 23 (11), 2087-2098, 2015 | 81 | 2015 |
Antiparallel protocadherin homodimers use distinct affinity-and specificity-mediating regions in cadherin repeats 1-4 JM Nicoludis, BE Vogt, AG Green, CPI Schärfe, DS Marks, R Gaudet Elife 5, e18449, 2016 | 63 | 2016 |
Standards‐based metadata management for molecular simulations R Grunzke, S Breuers, S Gesing, S Herres‐Pawlis, M Kruse, D Blunk, ... Concurrency and Computation: Practice and Experience 26 (10), 1744-1759, 2014 | 36 | 2014 |
Open community challenge reveals molecular network modules with key roles in diseases S Choobdar, ME Ahsen, J Crawford, M Tomasoni, T Fang, D Lamparter, ... bioRxiv, 265553, 2018 | 28 | 2018 |
Population-specific design of de-immunized protein biotherapeutics B Schubert, C Schärfe, P Dönnes, T Hopf, D Marks, O Kohlbacher PLoS computational biology 14 (3), e1005983, 2018 | 24 | 2018 |
Sequence co-evolution gives 3D contacts and structures of protein complexes. eLife 3 TA Hopf, CPI Schärfe, J Rodrigues, AG Green, O Kohlbacher, C Sander, ... eLife Sciences Publications Limited 3, e03430, 2014 | 18 | 2014 |
From the Desktop to the Grid: conversion of KNIME Workflows to gUSE. L de la Garza, J Krüger, C Schärfe, M Röttig, S Aiche, K Reinert, ... IWSG, 2013 | 14 | 2013 |
Structure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channel Y Gofman, C Schärfe, DS Marks, T Haliloglu, N Ben-Tal PLoS Computational Biology 10 (12), e1003976, 2014 | 12 | 2014 |
Ballaxy: web services for structural bioinformatics AK Hildebrandt, D Stöckel, NM Fischer, L de la Garza, J Krüger, S Nickels, ... Bioinformatics 31 (1), 121-122, 2015 | 10 | 2015 |
ClinVAP: a reporting strategy from variants to therapeutic options B Sürün, CPI Schärfe, MR Divine, J Heinrich, NC Toussaint, ... Bioinformatics 36 (7), 2316-2317, 2020 | 5 | 2020 |
Molecular epidemiology as an effective tool for the diagnosis and control of PRRSV infections in pig farms, illustrated using five cases. T Frey, A Richter, J Skrypski, C Schaerfe, M Hoferer | 2 | 2017 |
Research Collection B Sürün, CPI Schärfe, MR Divine, J Heinrich, NC Toussaint Bioinformatics 36 (7), 2316-2317, 2020 | | 2020 |
Towards personalized medicine: computational approaches to support drug design and clinical decision making CPI Schärfe Universität Tübingen, 2019 | | 2019 |