| Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function C Chiang, Y Litingtung, E Lee, KE Young, JL Corden, H Westphal, ... Nature 383 (6599), 407, 1996 | 3713 | 1996 |
| The Hedgehog and Wnt signalling pathways in cancer J Taipale, PA Beachy nature 411 (6835), 349-354, 2001 | 1921 | 2001 |
| Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened JK Chen, J Taipale, MK Cooper, PA Beachy Genes & development 16 (21), 2743-2748, 2002 | 1776 | 2002 |
| Cholesterol modification of hedgehog signaling proteins in animal development JA Porter, KE Young, PA Beachy Science 274 (5285), 255-259, 1996 | 1707 | 1996 |
| Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours DM Berman, SS Karhadkar, A Maitra, R Montes de Oca, MR Gerstenblith, ... Nature 425 (6960), 846-851, 2003 | 1652 | 2003 |
| Tissue repair and stem cell renewal in carcinogenesis PA Beachy, SS Karhadkar, DM Berman Nature 432 (7015), 324-331, 2004 | 1600 | 2004 |
| Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine J Taipale, JK Chen, MK Cooper, B Wang, RK Mann, L Milenkovic, ... Nature 406 (6799), 1005-1009, 2000 | 1589 | 2000 |
| Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer DN Watkins, DM Berman, SG Burkholder, B Wang, PA Beachy, SB Baylin Nature 422 (6929), 313-317, 2003 | 1409 | 2003 |
| Hedgehog signalling in prostate regeneration, neoplasia and metastasis SS Karhadkar, G Steven Bova, N Abdallah, S Dhara, D Gardner, A Maitra, ... Nature 431 (7009), 707-712, 2004 | 1376 | 2004 |
| Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb B Wang, JF Fallon, PA Beachy Cell 100 (4), 423-434, 2000 | 1184 | 2000 |
| Small molecule modulation of Smoothened activity JK Chen, J Taipale, KE Young, T Maiti, PA Beachy Proceedings of the National Academy of Sciences 99 (22), 14071-14076, 2002 | 1142 | 2002 |
| Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia C Zhao, A Chen, CH Jamieson, M Fereshteh, A Abrahamsson, J Blum, ... Nature 458 (7239), 776-779, 2009 | 1134 | 2009 |
| Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis H Roelink, JA Porter, C Chiang, Y Tanabe, DT Chang, PA Beachy, ... Cell 81 (3), 445-455, 1995 | 1131 | 1995 |
| Teratogen-mediated inhibition of target tissue response to Shh signaling MK Cooper, JA Porter, KE Young, PA Beachy Science 280 (5369), 1603-1607, 1998 | 1084 | 1998 |
| Medulloblastoma growth inhibition by hedgehog pathway blockade DM Berman, SS Karhadkar, AR Hallahan, JI Pritchard, CG Eberhart, ... Science 297 (5586), 1559-1561, 2002 | 1036 | 2002 |
| The Hedgehog response network: sensors, switches, and routers L Lum, PA Beachy science 304 (5678), 1755-1759, 2004 | 1027 | 2004 |
| Patched acts catalytically to suppress the activity of Smoothened J Taipale, MK Cooper, T Maiti, PA Beachy Nature 418 (6900), 892-896, 2002 | 1022 | 2002 |
| Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris: The Tabula Muris Consortium N Schaum, J Karkanias, NF Neff, AP May, SR Quake, T Wyss-Coray, ... Nature 562 (7727), 367, 2018 | 814 | 2018 |
| Molecular genetics of the bithorax complex in Drosophila melanogaster W Bender, M Akam, F Karch, PA Beachy, M Peifer, P Spierer, EB Lewis, ... Science 221 (4605), 23-29, 1983 | 764 | 1983 |
| Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog JJ Lee, DP von Kessler, S Parks, PA Beachy Cell 71 (1), 33-50, 1992 | 736 | 1992 |
