Alexander Mankin
Alexander Mankin
University of Illinois at Chicagp
Verified email at
Cited by
Cited by
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action
JA Dunkle, L Xiong, AS Mankin, JHD Cate
Proceedings of the national academy of sciences 107 (40), 17152-17157, 2010
Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
SM Toh, L Xiong, CA Arias, MV Villegas, K Lolans, J Quinn, AS Mankin
Molecular microbiology 64 (6), 1506-1514, 2007
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria
KL Leach, SM Swaney, JR Colca, WG McDonald, JR Blinn, LM Thomasco, ...
Molecular cell 26 (3), 393-402, 2007
Macrolide antibiotics: binding site, mechanism of action, resistance
M Gaynor, AS Mankin
Current topics in medicinal chemistry 3 (9), 949-960, 2003
How macrolide antibiotics work
N Vázquez-Laslop, AS Mankin
Trends in biochemical sciences 43 (9), 668-684, 2018
Molecular mechanism of drug-dependent ribosome stalling
N Vazquez-Laslop, C Thum, AS Mankin
Molecular cell 30 (2), 190-202, 2008
Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center
P Kloss, L Xiong, DL Shinabarger, AS Mankin
Journal of molecular biology 294 (1), 93-101, 1999
Nucleotide biosynthesis is critical for growth of bacteria in human blood
S Samant, H Lee, M Ghassemi, J Chen, JL Cook, AS Mankin, AA Neyfakh
PLoS pathogens 4 (2), e37, 2008
The ribosomal peptidyl transferase center: structure, function, evolution, inhibition
N Polacek, AS Mankin
Critical reviews in biochemistry and molecular biology 40 (5), 285-311, 2005
Protein synthesis by ribosomes with tethered subunits
C Orelle, ED Carlson, T Szal, T Florin, MC Jewett, AS Mankin
Nature 524 (7563), 119-124, 2015
Oxazolidinone Resistance Mutations in 23S rRNA ofEscherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action
L Xiong, P Kloss, S Douthwaite, NM Andersen, S Swaney, ...
Journal of bacteriology 182 (19), 5325-5331, 2000
Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide
N Polacek, M Gaynor, A Yassin, AS Mankin
Nature 411 (6836), 498-501, 2001
Antibiotics and the ribosome
T Tenson, A Mankin
Molecular microbiology 59 (6), 1664-1677, 2006
The general mode of translation inhibition by macrolide antibiotics
K Kannan, P Kanabar, D Schryer, T Florin, E Oh, N Bahroos, T Tenson, ...
Proceedings of the National Academy of Sciences 111 (45), 15958-15963, 2014
A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre
L Xiong, S Shah, P Mauvais, AS Mankin
Molecular microbiology 31 (2), 633-639, 1999
Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics
JR Colca, WG McDonald, DJ Waldon, LM Thomasco, RC Gadwood, ...
Journal of Biological Chemistry 278 (24), 21972-21979, 2003
Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA
G Garza-Ramos, L Xiong, P Zhong, A Mankin
Journal of Bacteriology 183 (23), 6898-6907, 2001
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA
F Yan, JM LaMarre, R Röhrich, J Wiesner, H Jomaa, AS Mankin, ...
Journal of the American Chemical Society 132 (11), 3953-3964, 2010
Programmed drug‐dependent ribosome stalling
H Ramu, A Mankin, N Vazquez‐Laslop
Molecular microbiology 71 (4), 811-824, 2009
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide
N Vázquez‐Laslop, H Ramu, D Klepacki, K Kannan, AS Mankin
The EMBO journal 29 (18), 3108-3117, 2010
The system can't perform the operation now. Try again later.
Articles 1–20