Evangelos Pazarentzos, Ph.D.
Evangelos Pazarentzos, Ph.D.
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
The Hippo effector YAP promotes resistance to RAF-and MEK-targeted cancer therapies
L Lin, AJ Sabnis, E Chan, V Olivas, L Cade, E Pazarentzos, S Asthana, ...
Nature genetics 47 (3), 250-256, 2015
3702015
Fis1 and Bap31 bridge the mitochondria–ER interface to establish a platform for apoptosis induction
R Iwasawa, AL Mahul‐Mellier, C Datler, E Pazarentzos, S Grimm
The EMBO journal 30 (3), 556-568, 2011
3552011
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas
M Elkabets, E Pazarentzos, D Juric, Q Sheng, RA Pelossof, S Brook, ...
Cancer cell 27 (4), 533-546, 2015
2252015
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer
G Hrustanovic, V Olivas, E Pazarentzos, A Tulpule, S Asthana, ...
Nature medicine 21 (9), 1038-1047, 2015
2032015
NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer
CM Blakely, E Pazarentzos, V Olivas, S Asthana, JJ Yan, I Tan, ...
Cell reports 11 (1), 98-110, 2015
1362015
Specific disintegration of complex II succinate: ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction
A Lemarie, L Huc, E Pazarentzos, AL Mahul-Mellier, S Grimm
Cell Death & Differentiation 18 (2), 338-349, 2011
1032011
Mitochondrial Ca 2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction
MS Hwang, CT Schwall, E Pazarentzos, C Datler, NN Alder, S Grimm
Cell Death & Differentiation 21 (11), 1733-1745, 2014
752014
De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF
AL Mahul-Mellier, E Pazarentzos, C Datler, R Iwasawa, G AbuAli, B Lin, ...
Cell Death & Differentiation 19 (5), 891-899, 2012
652012
Adaptive stress signaling in targeted cancer therapy resistance
E Pazarentzos, TG Bivona
Oncogene 34 (45), 5599-5606, 2015
512015
Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ D1067V kinase domain mutation
E Pazarentzos, P Giannikopoulos, G Hrustanovic, J St John, VR Olivas, ...
Oncogene 35 (9), 1198-1205, 2016
362016
Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution
VD Jonsson, CM Blakely, L Lin, S Asthana, N Matni, V Olivas, ...
Scientific reports 7 (1), 1-14, 2017
302017
CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex
C Datler, E Pazarentzos, AL Mahul-Mellier, W Chaisaklert, MS Hwang, ...
Journal of cell science 127 (8), 1816-1828, 2014
252014
IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention
E Pazarentzos, AL Mahul‐Mellier, C Datler, W Chaisaklert, MS Hwang, ...
The EMBO journal 33 (23), 2814-2828, 2014
222014
De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1
AL Mahul-Mellier, C Datler, E Pazarentzos, B Lin, W Chaisaklert, G Abuali, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (8), 1353-1365, 2012
222012
Dose-dependent neuroprotection of VEGF165 in Huntington's disease striatum
SM Ellison, A Trabalza, V Tisato, E Pazarentzos, S Lee, V Papadaki, ...
Molecular Therapy 21 (10), 1862-1875, 2013
182013
The transporter and permeability interactions of asymmetric dimethylarginine (ADMA) and L-arginine with the human blood–brain barrier in vitro
CP Watson, E Pazarentzos, M Fidanboylu, B Padilla, R Brown, ...
Brain research 1648, 232-242, 2016
112016
Integrated systems and methods for automated processing and analysis of biological samples, clinical information processing and clinical trial matching
T Matsuguchi, JAS John, E Pazarentzos, W Polkinghorn, ...
US Patent App. 15/727,501, 2018
102018
The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis
G AbuAli, W Chaisaklert, E Stelloo, E Pazarentzos, MS Hwang, D Qize, ...
Oncogene 34 (13), 1718-1728, 2015
92015
Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers
N Chatterjee, E Pazarentzos, MK Mayekar, P Gui, DV Allegakoen, ...
Cell reports 28 (9), 2317-2330. e8, 2019
72019
Anticancer gene transfer for cancer gene therapy
E Pazarentzos, ND Mazarakis
Anticancer Genes, 255-280, 2014
62014
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Articles 1–20