Sjoerd Wanrooij
Sjoerd Wanrooij
Associate Professor
Verified email at - Homepage
Cited by
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Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria
JN Spelbrink, FY Li, V Tiranti, K Nikali, QP Yuan, M Tariq, S Wanrooij, ...
Nature genetics 28 (3), 223-231, 2001
What causes mitochondrial DNA deletions in human cells?
KJ Krishnan, AK Reeve, DC Samuels, PF Chinnery, JK Blackwood, ...
Nature genetics 40 (3), 275-279, 2008
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice
H Tyynismaa, KP Mjosund, S Wanrooij, I Lappalainen, E Ylikallio, ...
Proceedings of the National Academy of Sciences 102 (49), 17687-17692, 2005
Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication
JM Fusté, S Wanrooij, E Jemt, CE Granycome, TJ Cluett, Y Shi, ...
Molecular cell 37 (1), 67-78, 2010
Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro
S Wanrooij, JM Fusté, G Farge, Y Shi, CM Gustafsson, M Falkenberg
Proceedings of the National Academy of Sciences 105 (32), 11122-11127, 2008
Mammalian transcription factor A is a core component of the mitochondrial transcription machinery
Y Shi, A Dierckx, PH Wanrooij, S Wanrooij, NG Larsson, LM Wilhelmsson, ...
Proceedings of the National Academy of Sciences 109 (41), 16510-16515, 2012
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells
JLO Pohjoismäki, S Wanrooij, AK Hyvärinen, S Goffart, IJ Holt, ...
Nucleic acids research 34 (20), 5815-5828, 2006
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes
S Wanrooij, S Goffart, JLO Pohjoismäki, T Yasukawa, JN Spelbrink
Nucleic acids research 35 (10), 3238-3251, 2007
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA
AK Hyvärinen, JLO Pohjoismäki, A Reyes, S Wanrooij, T Yasukawa, ...
Nucleic acids research 35 (19), 6458-6474, 2007
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA …
S Goffart, HM Cooper, H Tyynismaa, S Wanrooij, A Suomalainen, ...
Human molecular genetics 18 (2), 328-340, 2009
Twinkle and POLG defects enhance age‐dependent accumulation of mutations in the control region of mtDNA
S Wanrooij, P Luoma, G Van Goethem, C Van Broeckhoven, ...
Nucleic acids research 32 (10), 3053-3064, 2004
In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication
J Miralles Fusté, Y Shi, S Wanrooij, X Zhu, E Jemt, Ö Persson, N Sabouri, ...
PLoS genetics 10 (12), e1004832, 2014
The human mitochondrial replication fork in health and disease
S Wanrooij, M Falkenberg
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1797 (8), 1378-1388, 2010
PrimPol is required for replication reinitiation after mtDNA damage
R Torregrosa-Muñumer, JME Forslund, S Goffart, A Pfeiffer, G Stojkovič, ...
Proceedings of the National Academy of Sciences 114 (43), 11398-11403, 2017
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication
S Wanrooij, J Miralles Fusté, JB Stewart, PH Wanrooij, T Samuelsson, ...
EMBO reports 13 (12), 1130-1137, 2012
ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells
N Al-Furoukh, A Ianni, H Nolte, S Hölper, M Krüger, S Wanrooij, T Braun
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (10), 2580-2591, 2015
ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia
HM Cooper, Y Yang, E Ylikallio, R Khairullin, R Woldegebriel, KL Lin, ...
Human molecular genetics 26 (8), 1432-1443, 2017
Oxidative DNA damage stalls the human mitochondrial replisome
G Stojkovič, AV Makarova, PH Wanrooij, J Forslund, PM Burgers, ...
Scientific reports 6 (1), 1-13, 2016
Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired
PH Wanrooij, MKM Engqvist, JME Forslund, C Navarrete, AK Nilsson, ...
Proceedings of the National Academy of Sciences 114 (47), 12466-12471, 2017
Quinazoline ligands induce cancer cell death through selective STAT3 inhibition and G-quadruplex stabilization
J Jamroskovic, M Doimo, K Chand, I Obi, R Kumar, K Brännström, ...
Journal of the American Chemical Society 142 (6), 2876-2888, 2020
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