Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU. 1 axis SF Libregts, L Gutiérrez, AM de Bruin, FM Wensveen, P Papadopoulos, ... Blood, The Journal of the American Society of Hematology 118 (9), 2578-2588, 2011 | 244 | 2011 |
Interferon-γ impairs proliferation of hematopoietic stem cells in mice AM de Bruin, Ö Demirel, B Hooibrink, CH Brandts, MA Nolte Blood, The Journal of the American Society of Hematology 121 (18), 3578-3585, 2013 | 235 | 2013 |
Impact of interferon-γ on hematopoiesis AM de Bruin, C Voermans, MA Nolte Blood, The Journal of the American Society of Hematology 124 (16), 2479-2486, 2014 | 202 | 2014 |
Eosinophil differentiation in the bone marrow is inhibited by T cell–derived IFN-γ AM de Bruin, M Buitenhuis, KF van der Sluijs, KPJM van Gisbergen, ... Blood, The Journal of the American Society of Hematology 116 (14), 2559-2569, 2010 | 75 | 2010 |
Erythropoietin accelerates smooth muscle cell–rich vascular lesion formation in mice through endothelial cell activation involving enhanced PDGF-BB release ML Janmaat, JLT Heerkens, AM de Bruin, A Klous, V de Waard, ... Blood, The Journal of the American Society of Hematology 115 (7), 1453-1460, 2010 | 73 | 2010 |
Activating mutations in c-KIT and PDGFRα are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes K Burger, MA den Bakker, JM Kros, AM de Bruin, W Oosterhuis, ... Cancer biology & therapy 4 (11), 1270-1274, 2005 | 65 | 2005 |
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins H Van Andel, Z Ren, I Koopmans, SPJ Joosten, KA Kocemba, W De Lau, ... Proceedings of the National Academy of Sciences 114 (2), 376-381, 2017 | 43 | 2017 |
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation FM Wensveen, IAM Derks, KPJM Van Gisbergen, AM De Bruin, ... Blood, The Journal of the American Society of Hematology 119 (6), 1440-1449, 2012 | 40 | 2012 |
Continuous CD27 triggering in vivo strongly reduces NK cell numbers V De Colvenaer, S Taveirne, J Hamann, AM de Bruin, M De Smedt, ... European journal of immunology 40 (4), 1107-1117, 2010 | 32 | 2010 |
The DNA damage response regulates RAG1/2 expression in pre–B cells through ATM-FOXO1 signaling K Ochodnicka-Mackovicova, M Bahjat, C Maas, A Van Der Veen, ... The Journal of Immunology 197 (7), 2918-2929, 2016 | 30 | 2016 |
NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity K Ochodnicka-Mackovicova, M Bahjat, TA Bloedjes, C Maas, AM de Bruin, ... Blood, The Journal of the American Society of Hematology 126 (11), 1324-1335, 2015 | 25 | 2015 |
A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense H Veninga, RM Hoek, AF de Vos, AM de Bruin, FQ An, T van der Poll, ... PLoS One 6 (10), e24431, 2011 | 22 | 2011 |
CD70-driven chronic immune activation is protective against atherosclerosis RW Van Olffen, AM De Bruin, M Vos, AD Staniszewska, J Hamann, ... Journal of innate immunity 2 (4), 344-352, 2010 | 21 | 2010 |
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation PM Vink, WM Smout, LJ Driessen-Engels, AM de Bruin, D Delsing, ... PloS one 8 (3), e57348, 2013 | 12 | 2013 |
Interferon-gamma induces monopoiesis and inhibits neutrophil development during inflammation AM de Bruin, MG Valkhof, L Boon, IP Touw, MA Nolte Blood, The Journal of the American Society of Hematology 118 (21), 1320-1320, 2011 | 3 | 2011 |
in mice induces anemia by reducing erythrocyte lifespan and inhibiting erythropoiesis through an IRF-1/PU. 1-axis SF Libregts, L Gutiérrez, AM de Bruin, FM Wensveen, P Papadopoulos, ... Immune activation and lineage fate decisions: Inducing a shift of program …, 2011 | | 2011 |
CD55 regulates CD97 expression, granulopoietic activity, and anti-bacterial host defense H Veninga, RM Hoek, AF de Vos, AM de Bruin, D Flierman, FQ An, ... In vivo studies on the role of Adhesion-GPCR CD97 in immunity, 77, 2010 | | 2010 |
CHAPTER VI CHAPTER VI FM Wensveen, IAM Derks, AM de Bruin, KPJM van Gisbergen, MA Nolte, ... Survival of the fittest clone: Pro-apoptotic protein Noxa controls selection …, 0 | | |
BH3-only protein Noxa plays a role in the regulation of early erythropoiesis FM Wensveen, CR Geest, SFWM Libregts, AM de Bruin, IAM Derks, ... Survival of the fittest clone: Pro-apoptotic protein Noxa controls selection …, 0 | | |
function during ontogeny of the hematopoietic system SF Libregts, C Orelio, N Legrand, AM de Bruin, S Klamer, C Voermans, ... Immune activation and lineage fate decisions: Inducing a shift of program, 55, 0 | | |