| Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant α-synuclein X Lin, L Parisiadou, XL Gu, L Wang, H Shim, L Sun, C Xie, CX Long, ... Neuron 64 (6), 807-827, 2009 | 580 | 2009 |
| Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis L Parisiadou, C Xie, HJ Cho, X Lin, XL Gu, CX Long, E Lobbestael, ... Journal of Neuroscience 29 (44), 13971-13980, 2009 | 368 | 2009 |
| MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein HJ Cho, G Liu, SM Jin, L Parisiadou, C Xie, J Yu, L Sun, B Ma, J Ding, ... Human molecular genetics 22 (3), 608-620, 2013 | 291 | 2013 |
| The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2 L Wang, C Xie, E Greggio, L Parisiadou, H Shim, L Sun, J Chandran, ... Journal of Neuroscience 28 (13), 3384-3391, 2008 | 227 | 2008 |
| LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity L Parisiadou, J Yu, C Sgobio, C Xie, G Liu, L Sun, XL Gu, X Lin, ... Nature neuroscience 17 (3), 367-376, 2014 | 203 | 2014 |
| Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of … X Lin, L Parisiadou, C Sgobio, G Liu, J Yu, L Sun, H Shim, XL Gu, J Luo, ... Journal of Neuroscience 32 (27), 9248-9264, 2012 | 197 | 2012 |
| Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis R Tao, A Vassilopoulos, L Parisiadou, Y Yan, D Gius Antioxidants & redox signaling 20 (10), 1646-1654, 2014 | 181 | 2014 |
| Loss of NAD-dependent protein deacetylase sirtuin-2 alters mitochondrial protein acetylation and dysregulates mitophagy G Liu, SH Park, M Imbesi, WJ Nathan, X Zou, Y Zhu, H Jiang, L Parisiadou, ... Antioxidants & redox signaling 26 (15), 849-863, 2017 | 127 | 2017 |
| Leucine‐rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export HJ Cho, J Yu, C Xie, P Rudrabhatla, X Chen, J Wu, L Parisiadou, G Liu, ... The EMBO journal 33 (20), 2314-2331, 2014 | 88 | 2014 |
| LRRK2 function on actin and microtubule dynamics in Parkinson’s disease L Parisiadou, H Cai Communicative & integrative biology 3 (5), 396-400, 2010 | 82 | 2010 |
| A calcineurin-and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons J Luo, L Sun, X Lin, G Liu, J Yu, L Parisiadou, C Xie, J Ding, H Cai Human molecular genetics 23 (24), 6567-6574, 2014 | 72 | 2014 |
| Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine … G Liu, C Sgobio, X Gu, L Sun, X Lin, J Yu, L Parisiadou, C Xie, N Sastry, ... Human molecular genetics 24 (18), 5299-5312, 2015 | 56 | 2015 |
| Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11α L Parisiadou, S Efthimiopoulos Neurobiology of aging 28 (3), 377-388, 2007 | 56 | 2007 |
| Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production L Parisiadou, I Bethani, V Michaki, K Krousti, G Rapti, S Efthimiopoulos Neurobiology of disease 30 (3), 353-364, 2008 | 46 | 2008 |
| Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription L Parisiadou, A Fassa, A Fotinopoulou, I Bethani, S Efthimiopoulos Neurodegenerative Diseases 1 (4-5), 184-191, 2004 | 44 | 2004 |
| Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course N Tayebi, L Parisiadou, B Berhe, AN Gonzalez, J Serra-Vinardell, ... Molecular genetics and metabolism 122 (4), 198-208, 2017 | 34 | 2017 |
| Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations C Chen, G Soto, V Dumrongprechachan, N Bannon, S Kang, ... Elife 9, e58997, 2020 | 29 | 2020 |
| LRRK2 at striatal synapses: cell-type specificity and mechanistic insights PD Skelton, V Tokars, L Parisiadou Cells 11 (1), 169, 2022 | 12 | 2022 |
| Pathogenic LRRK2 R1441C mutation is associated with striatal alterations HS Xenias, C Chen, S Kang, S Cherian, X Situ, B Shanmugasundaram, ... bioRxiv, 2020.03. 11.986455, 2020 | 4 | 2020 |
| R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations HS Xenias, C Chen, S Kang, S Cherian, X Situ, B Shanmugasundaram, ... Communications biology 5 (1), 1211, 2022 | 3 | 2022 |
Huaibin CaiSenior Investigator, National Institute on Aging, National Institutes of HealthVerified email at mail.nih.gov
