| Probing the physicochemical boundaries of cell permeability and oral bioavailability in lipophilic macrocycles inspired by natural products AT Bockus, KW Lexa, CR Pye, AS Kalgutkar, JW Gardner, KCR Hund, ... Journal of Medicinal Chemistry 58 (11), 4581-4589, 2015 | 150 | 2015 |
| Nonclassical size dependence of permeation defines bounds for passive adsorption of large drug molecules CR Pye, WM Hewitt, J Schwochert, TD Haddad, CE Townsend, L Etienne, ... Journal of medicinal chemistry 60 (5), 1665-1672, 2017 | 133 | 2017 |
| Lipophilic permeability efficiency reconciles the opposing roles of lipophilicity in membrane permeability and aqueous solubility MR Naylor, AM Ly, MJ Handford, DP Ramos, CR Pye, A Furukawa, ... Journal of medicinal chemistry 61 (24), 11169-11182, 2018 | 130 | 2018 |
| Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of … AT Bockus, JA Schwochert, CR Pye, CE Townsend, V Sok, MA Bednarek, ... Journal of Medicinal Chemistry 58 (18), 7409-7418, 2015 | 123 | 2015 |
| Passive membrane permeability in cyclic peptomer scaffolds is robust to extensive variation in side chain functionality and backbone geometry A Furukawa, CE Townsend, J Schwochert, CR Pye, MA Bednarek, ... Journal of Medicinal Chemistry 59 (20), 9503-9512, 2016 | 92 | 2016 |
| Peptide to peptoid substitutions increase cell permeability in cyclic hexapeptides J Schwochert, R Turner, M Thang, RF Berkeley, AR Ponkey, ... Organic letters 17 (12), 2928-2931, 2015 | 90 | 2015 |
| Stereochemistry balances cell permeability and solubility in the naturally derived phepropeptin cyclic peptides J Schwochert, Y Lao, CR Pye, MR Naylor, PV Desai, ... ACS Medicinal Chemistry Letters 7 (8), 757-761, 2016 | 61 | 2016 |
| Drug‐like properties in macrocycles above MW 1000: backbone rigidity versus side‐chain lipophilicity A Furukawa, J Schwochert, CR Pye, D Asano, QD Edmondson, ... Angewandte Chemie International Edition 59 (48), 21571-21577, 2020 | 54 | 2020 |
| Geometrically diverse lariat peptide scaffolds reveal an untapped chemical space of high membrane permeability CN Kelly, CE Townsend, AN Jain, MR Naylor, CR Pye, J Schwochert, ... Journal of the American Chemical Society 143 (2), 705-714, 2020 | 33 | 2020 |
| Using 1 H and 13 C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach QNN Nguyen, J Schwochert, DJ Tantillo, RS Lokey Physical Chemistry Chemical Physics 20 (20), 14003-14012, 2018 | 31 | 2018 |
| Synthetic cyclic peptomers as type III secretion system inhibitors H Lam, J Schwochert, Y Lao, T Lau, C Lloyd, J Luu, O Kooner, J Morgan, ... Antimicrobial agents and chemotherapy 61 (9), 10.1128/aac. 00060-17, 2017 | 19 | 2017 |
| Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides J Schwochert, C Pye, C Ahlbach, Y Abdollahian, K Farley, B Khunte, ... Organic letters 16 (23), 6088-6091, 2014 | 16 | 2014 |
| CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry C Townsend, A Furukawa, J Schwochert, CR Pye, Q Edmondson, ... Bioorganic & Medicinal Chemistry 26 (6), 1232-1238, 2018 | 14 | 2018 |
| Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides CM Theodore, N Lorig-Roach, PC Still, TA Johnson, M Drašković, ... Journal of natural products 78 (3), 441-452, 2015 | 12 | 2015 |
| Identifying the cellular target of cordyheptapeptide A and synthetic derivatives VG Klein, WM Bray, HY Wang, Q Edmondson, J Schwochert, S Ono, ... ACS chemical biology 16 (8), 1354-1364, 2021 | 6 | 2021 |
| The passive permeability landscape around geometrically diverse hexa-and heptapeptide macrocycles C Townsend, E Jason, MR Naylor, CR Pye, JA Schwochert, ... | 5 | 2020 |
| Amide-to-ester substitutions modify the permeability and ADME properties of natural and synthetic cyclic peptides M Naylor, A Ly, J Schwochert, P Desai, ICG Valcarcel, J Barrett, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 252, 2016 | 1 | 2016 |
| DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor AP Silvestri, Q Zhang, Y Ping, EW Muir, J Zhao, SK Chakka, G Wang, ... ACS Medicinal Chemistry Letters 14 (6), 820-826, 2023 | | 2023 |
| Abstract B018: The development of macrocyclic peptide Ras inhibitors K Josephson, A Silvestri, JL Fribourgh, WM Bray, B David, CC Hanna, ... Molecular Cancer Research 21 (5_Supplement), B018-B018, 2023 | | 2023 |
| Cell-permeable cyclic peptides and uses thereof PYE Cameron, J Schwochert, S Rubin, A Silvestri US Patent App. 17/750,110, 2022 | | 2022 |
