| Retrospective analysis of natural products provides insights for future discovery trends CR Pye, MJ Bertin, RS Lokey, WH Gerwick, RG Linington Proceedings of the National Academy of Sciences 114 (22), 5601-5606, 2017 | 533 | 2017 |
| Cell-permeable cyclic peptides from synthetic libraries inspired by natural products WM Hewitt, SSF Leung, CR Pye, AR Ponkey, M Bednarek, MP Jacobson, ... Journal of the American Chemical Society 137 (2), 715-721, 2015 | 232 | 2015 |
| Probing the physicochemical boundaries of cell permeability and oral bioavailability in lipophilic macrocycles inspired by natural products AT Bockus, KW Lexa, CR Pye, AS Kalgutkar, JW Gardner, KCR Hund, ... Journal of Medicinal Chemistry 58 (11), 4581-4589, 2015 | 150 | 2015 |
| Nonclassical size dependence of permeation defines bounds for passive adsorption of large drug molecules CR Pye, WM Hewitt, J Schwochert, TD Haddad, CE Townsend, L Etienne, ... Journal of medicinal chemistry 60 (5), 1665-1672, 2017 | 133 | 2017 |
| Lipophilic permeability efficiency reconciles the opposing roles of lipophilicity in membrane permeability and aqueous solubility MR Naylor, AM Ly, MJ Handford, DP Ramos, CR Pye, A Furukawa, ... Journal of medicinal chemistry 61 (24), 11169-11182, 2018 | 130 | 2018 |
| Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of … AT Bockus, JA Schwochert, CR Pye, CE Townsend, V Sok, MA Bednarek, ... Journal of Medicinal Chemistry 58 (18), 7409-7418, 2015 | 123 | 2015 |
| Passive membrane permeability in cyclic peptomer scaffolds is robust to extensive variation in side chain functionality and backbone geometry A Furukawa, CE Townsend, J Schwochert, CR Pye, MA Bednarek, ... Journal of Medicinal Chemistry 59 (20), 9503-9512, 2016 | 92 | 2016 |
| Stereochemistry balances cell permeability and solubility in the naturally derived phepropeptin cyclic peptides J Schwochert, Y Lao, CR Pye, MR Naylor, PV Desai, ... ACS Medicinal Chemistry Letters 7 (8), 757-761, 2016 | 61 | 2016 |
| Drug‐like properties in macrocycles above MW 1000: backbone rigidity versus side‐chain lipophilicity A Furukawa, J Schwochert, CR Pye, D Asano, QD Edmondson, ... Angewandte Chemie International Edition 59 (48), 21571-21577, 2020 | 54 | 2020 |
| NP analyst: an open online platform for compound activity mapping S Lee, JA van Santen, N Farzaneh, DY Liu, CR Pye, TUH Baumeister, ... ACS Central Science 8 (2), 223-234, 2022 | 34 | 2022 |
| Geometrically diverse lariat peptide scaffolds reveal an untapped chemical space of high membrane permeability CN Kelly, CE Townsend, AN Jain, MR Naylor, CR Pye, J Schwochert, ... Journal of the American Chemical Society 143 (2), 705-714, 2020 | 33 | 2020 |
| Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides J Schwochert, C Pye, C Ahlbach, Y Abdollahian, K Farley, B Khunte, ... Organic letters 16 (23), 6088-6091, 2014 | 16 | 2014 |
| The functional group on (E)-4,4′–disubstituted stilbenes influences toxicity and antioxidative activity in differentiated PC-12 cells GX Garcia, SW Larsen, C Pye, M Galbreath, R Isovitsch, EA Fradinger Bioorganic & medicinal chemistry letters 23 (23), 6355-6359, 2013 | 15 | 2013 |
| CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry C Townsend, A Furukawa, J Schwochert, CR Pye, Q Edmondson, ... Bioorganic & Medicinal Chemistry 26 (6), 1232-1238, 2018 | 14 | 2018 |
| The Synthesis, Photophysical Characterization, and X‐Ray Structure Analysis of Two Polymorphs of 4, 4′‐Diacetylstilbene C Pye, FR Fronczek, R Isovitsch Helvetica Chimica Acta 93 (6), 1162-1171, 2010 | 6 | 2010 |
| The passive permeability landscape around geometrically diverse hexa-and heptapeptide macrocycles C Townsend, E Jason, MR Naylor, CR Pye, JA Schwochert, ... | 5 | 2020 |
| Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high CR Pye, MJ Bertin, RS Lokey, WH Gerwick, RG Linington Proceedings of the National Academy of Sciences 114 (31), E6273-E6273, 2017 | 5 | 2017 |
| A strategy for direct chemical activation of the retinoblastoma protein CR Pye, WM Bray, ER Brown, JR Burke, RS Lokey, SM Rubin ACS chemical biology 11 (5), 1192-1197, 2016 | 2 | 2016 |
| Natural products: Are we close to the end? CR Pye, MJ Bertin, RS Lokey, WH Gerwick, RG Linington Planta Medica 81 (11), IL63, 2015 | 1 | 2015 |
| Synthesis, structure, and spectroscopy of two benzil-based α-diimine ligands and their palladium (II) complexes M Kubota, D Covarrubias, C Pye, FR Fronczek, R Isovitsch Journal of Coordination Chemistry 66 (8), 1350-1362, 2013 | 1 | 2013 |
Scott LokeyUniversity of California Santa CruzVerified email at ucsc.edu
