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Cristina Cecchi
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A causative link between the structure of aberrant protein oligomers and their toxicity
S Campioni, B Mannini, M Zampagni, A Pensalfini, C Parrini, ...
Nature chemical biology 6 (2), 140-147, 2010
6292010
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ...
Science 358 (6369), 1440-1443, 2017
6032017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
3082017
Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer’s patients
C Cecchi, C Fiorillo, S Sorbi, S Latorraca, B Nacmias, S Bagnoli, P Nassi, ...
Free Radical Biology and Medicine 33 (10), 1372-1379, 2002
2122002
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity
B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, ...
ACS chemical biology 9 (10), 2309-2317, 2014
2092014
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, ...
Proceedings of the National Academy of Sciences 109 (31), 12479-12484, 2012
1682012
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
R Cascella, SW Chen, A Bigi, JD Camino, CK Xu, CM Dobson, F Chiti, ...
Nature communications 12 (1), 1814, 2021
1562021
SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
M Becatti, N Taddei, C Cecchi, N Nassi, PA Nassi, C Fiorillo
Cellular and Molecular Life Sciences 69, 2245-2260, 2012
1502012
Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease
C Cecchi, S Latorraca, S Sorbi, T Iantomasi, F Favilli, MT Vincenzini, ...
Neuroscience letters 275 (2), 152-154, 1999
1421999
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Nature communications 10 (1), 225, 2019
1342019
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
E Evangelisti, R Cascella, M Becatti, G Marrazza, CM Dobson, F Chiti, ...
Scientific reports 6 (1), 32721, 2016
1262016
The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity
C Cecchi, M Stefani
Biophysical chemistry 182, 30-43, 2013
1172013
Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates
C Cecchi, S Baglioni, C Fiorillo, A Pensalfini, G Liguri, D Nosi, S Rigacci, ...
Journal of cell science 118 (15), 3459-3470, 2005
1092005
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
1082018
Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-κB, and JNK pathways
C Fiorillo, M Becatti, A Pensalfini, C Cecchi, L Lanzilao, G Donzelli, ...
Free Radical Biology and Medicine 45 (6), 839-846, 2008
1082008
Calcium dyshomeostasis in Alzheimer’s disease pathogenesis
R Cascella, C Cecchi
International journal of molecular sciences 22 (9), 4914, 2021
1042021
Seladin‐1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
C Cecchi, F Rosati, A Pensalfini, L Formigli, D Nosi, G Liguri, F Dichiara, ...
Journal of cellular and molecular medicine 12 (5b), 1990-2002, 2008
982008
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers
E Evangelisti, C Cecchi, R Cascella, C Sgromo, M Becatti, CM Dobson, ...
Journal of cell science 125 (10), 2416-2427, 2012
892012
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro
R Cascella, S Conti, B Mannini, X Li, JN Buxbaum, B Tiribilli, F Chiti, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013
852013
Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies
R Cascella, C Capitini, G Fani, CM Dobson, C Cecchi, F Chiti
Journal of Biological Chemistry 291 (37), 19437-19448, 2016
842016
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