| Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, ... Science 358 (6369), 1440-1443, 2017 | 656 | 2017 |
| A causative link between the structure of aberrant protein oligomers and their toxicity S Campioni, B Mannini, M Zampagni, A Pensalfini, C Parrini, ... Nature chemical biology 6 (2), 140-147, 2010 | 636 | 2010 |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 325 | 2017 |
| Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, ... ACS chemical biology 9 (10), 2309-2317, 2014 | 223 | 2014 |
| Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer’s patients C Cecchi, C Fiorillo, S Sorbi, S Latorraca, B Nacmias, S Bagnoli, P Nassi, ... Free Radical Biology and Medicine 33 (10), 1372-1379, 2002 | 211 | 2002 |
| The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells R Cascella, SW Chen, A Bigi, JD Camino, CK Xu, CM Dobson, F Chiti, ... Nature communications 12 (1), 1814, 2021 | 181 | 2021 |
| Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, ... Proceedings of the National Academy of Sciences 109 (31), 12479-12484, 2012 | 171 | 2012 |
| SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes M Becatti, N Taddei, C Cecchi, N Nassi, PA Nassi, C Fiorillo Cellular and Molecular Life Sciences 69, 2245-2260, 2012 | 153 | 2012 |
| Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 147 | 2019 |
| Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease C Cecchi, S Latorraca, S Sorbi, T Iantomasi, F Favilli, MT Vincenzini, ... Neuroscience letters 275 (2), 152-154, 1999 | 137 | 1999 |
| Calcium dyshomeostasis in Alzheimer’s disease pathogenesis R Cascella, C Cecchi International journal of molecular sciences 22 (9), 4914, 2021 | 134 | 2021 |
| Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases E Evangelisti, R Cascella, M Becatti, G Marrazza, CM Dobson, F Chiti, ... Scientific reports 6 (1), 32721, 2016 | 133 | 2016 |
| The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity C Cecchi, M Stefani Biophysical chemistry 182, 30-43, 2013 | 121 | 2013 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 114 | 2018 |
| Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-κB, and JNK pathways C Fiorillo, M Becatti, A Pensalfini, C Cecchi, L Lanzilao, G Donzelli, ... Free Radical Biology and Medicine 45 (6), 839-846, 2008 | 109 | 2008 |
| Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates C Cecchi, S Baglioni, C Fiorillo, A Pensalfini, G Liguri, D Nosi, S Rigacci, ... Journal of cell science 118 (15), 3459-3470, 2005 | 108 | 2005 |
| Seladin‐1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content C Cecchi, F Rosati, A Pensalfini, L Formigli, D Nosi, G Liguri, F Dichiara, ... Journal of cellular and molecular medicine 12 (5b), 1990-2002, 2008 | 96 | 2008 |
| Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers E Evangelisti, C Cecchi, R Cascella, C Sgromo, M Becatti, CM Dobson, ... Journal of cell science 125 (10), 2416-2427, 2012 | 93 | 2012 |
| Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies R Cascella, C Capitini, G Fani, CM Dobson, C Cecchi, F Chiti Journal of Biological Chemistry 291 (37), 19437-19448, 2016 | 90 | 2016 |
| Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro R Cascella, S Conti, B Mannini, X Li, JN Buxbaum, B Tiribilli, F Chiti, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013 | 89 | 2013 |
