Effect of gene therapy on visual function in Leber's congenital amaurosis JWB Bainbridge, AJ Smith, SS Barker, S Robbie, R Henderson, ... New England Journal of Medicine 358 (21), 2231-2239, 2008 | 2401 | 2008 |
Retinal repair by transplantation of photoreceptor precursors RE MacLaren, RA Pearson, A MacNeil, RH Douglas, TE Salt, M Akimoto, ... Nature 444 (7116), 203-207, 2006 | 1296 | 2006 |
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector HB Gaspar, KL Parsley, S Howe, D King, KC Gilmour, J Sinclair, G Brouns, ... The Lancet 364 (9452), 2181-2187, 2004 | 834 | 2004 |
Long-term effect of gene therapy on Leber’s congenital amaurosis JWB Bainbridge, MS Mehat, V Sundaram, SJ Robbie, SE Barker, ... New England Journal of Medicine 372 (20), 1887-1897, 2015 | 795 | 2015 |
Effective gene therapy with nonintegrating lentiviral vectors RJ Yánez-Munoz, KS Balaggan, A MacNeil, SJ Howe, M Schmidt, ... Nature medicine 12 (3), 348-353, 2006 | 570 | 2006 |
Restoration of vision after transplantation of photoreceptors RA Pearson, AC Barber, M Rizzi, C Hippert, T Xue, EL West, Y Duran, ... Nature 485 (7396), 99-103, 2012 | 560 | 2012 |
Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix L Guo, SE Moss, RA Alexander, RR Ali, FW Fitzke, MF Cordeiro Investigative ophthalmology & visual science 46 (1), 175-182, 2005 | 459 | 2005 |
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina A Gonzalez-Cordero, EL West, RA Pearson, Y Duran, LS Carvalho, ... Nature biotechnology 31 (8), 741-747, 2013 | 447 | 2013 |
Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy RR Ali, GM Sarra, C Stephens, M Alwis, JWB Bainbridge, PM Munro, ... Nature genetics 25 (3), 306-310, 2000 | 399 | 2000 |
Gene transfer into the mouse retina mediated by an adeno-associated viral vector RR Ali, MB Reichel, AJ Thrasher, RJ Levinsky, C Kinnon, N Kanuga, ... Human molecular genetics 5 (5), 591-594, 1996 | 334 | 1996 |
Repair of the degenerate retina by photoreceptor transplantation AC Barber, C Hippert, Y Duran, EL West, JWB Bainbridge, ... Proceedings of the National Academy of Sciences 110 (1), 354-359, 2013 | 326 | 2013 |
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors RA Pearson, A Gonzalez-Cordero, EL West, JR Ribeiro, N Aghaizu, ... Nature communications 7 (1), 13029, 2016 | 300 | 2016 |
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells SA Nicklin, H Buening, KL Dishart, M De Alwis, A Girod, U Hacker, ... Molecular therapy 4 (3), 174-181, 2001 | 285 | 2001 |
Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector SL Hart, CV Arancibia-Cárcamo, MA Wolfert, C Mailhos, NJ O'reilly, ... Human gene therapy 9 (4), 575-585, 1998 | 266 | 1998 |
Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA T Sourisseau, A Georgiadis, A Tsapara, RR Ali, R Pestell, K Matter, ... Molecular and cellular biology, 2006 | 258 | 2006 |
Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium G Le Meur, K Stieger, AJ Smith, M Weber, JY Deschamps, D Nivard, ... Gene therapy 14 (4), 292-303, 2007 | 256 | 2007 |
The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages UFO Luhmann, S Robbie, PMG Munro, SE Barker, Y Duran, V Luong, ... Investigative ophthalmology & visual science 50 (12), 5934-5943, 2009 | 254 | 2009 |
In vivo gene transfer to the mouse eye using an HIV-based lentiviral vector; efficient long-term transduction of corneal endothelium and retinal pigment epithelium JWB Bainbridge, C Stephens, K Parsley, C Demaison, A Halfyard, ... Gene therapy 8 (21), 1665-1668, 2001 | 241 | 2001 |
Novel antisense oligonucleotides targeting TGF-β inhibit in vivo scarring and improve surgical outcome MF Cordeiro, A Mead, RR Ali, RA Alexander, S Murray, C Chen, ... Gene therapy 10 (1), 59-71, 2003 | 237 | 2003 |
Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration MS Mehat, V Sundaram, C Ripamonti, AG Robson, AJ Smith, S Borooah, ... Ophthalmology 125 (11), 1765-1775, 2018 | 226 | 2018 |